BACKGROUND: The technical limitation associated with submucosal injection of normal saline solution during EMR is the relatively short duration of mucosal elevation. The clinical application of a new method of EMR with submucosal injection of a fibrinogen mixture was evaluated. METHODS: Thirty-five early stage neoplastic gastric lesions were resected by EMR with submucosal injection of a fibrinogen mixture. The efficacy and clinical outcomes were analyzed. RESULTS: Additional submucosal injection was not required for any of the 35 lesions to complete the EMR with submucosal injection of a fibrinogen mixture procedure. The rates of en bloc resection and complete resection were, respectively, 82.9% and 88.6%. The en bloc resection rate was significantly lower for lesions over 20 mm in diameter (60% vs. 92%; p<0.05) and for lesions on the lesser curvature or posterior wall of the stomach compared with those on the greater curvature or anterior wall (55.6% vs. 92.3%; p<0.05). The rate of complete resection also was dependent on the size and location of the lesions. There was no major EMR with submucosal injection of a fibrinogen mixture related complication including bleeding or perforation. CONCLUSIONS: EMR with submucosal injection of a fibrinogen mixture is an easy, safe, and technically efficient method for complete EMR.
BACKGROUND: The technical limitation associated with submucosal injection of normal saline solution during EMR is the relatively short duration of mucosal elevation. The clinical application of a new method of EMR with submucosal injection of a fibrinogen mixture was evaluated. METHODS: Thirty-five early stage neoplastic gastric lesions were resected by EMR with submucosal injection of a fibrinogen mixture. The efficacy and clinical outcomes were analyzed. RESULTS: Additional submucosal injection was not required for any of the 35 lesions to complete the EMR with submucosal injection of a fibrinogen mixture procedure. The rates of en bloc resection and complete resection were, respectively, 82.9% and 88.6%. The en bloc resection rate was significantly lower for lesions over 20 mm in diameter (60% vs. 92%; p<0.05) and for lesions on the lesser curvature or posterior wall of the stomach compared with those on the greater curvature or anterior wall (55.6% vs. 92.3%; p<0.05). The rate of complete resection also was dependent on the size and location of the lesions. There was no major EMR with submucosal injection of a fibrinogen mixture related complication including bleeding or perforation. CONCLUSIONS: EMR with submucosal injection of a fibrinogen mixture is an easy, safe, and technically efficient method for complete EMR.
Authors: Soo Hoon Eun; Joo Young Cho; In Seop Jung; Bong Min Ko; Soo Jin Hong; Chang Beom Ryu; Jin Oh Kim; So Young Jin; Joon Seong Lee; Moon Sung Lee; Chan Sup Shim; Boo Sung Kim Journal: Gut Liver Date: 2007-06-30 Impact factor: 4.519
Authors: Ki Joo Kang; Byung-Hoon Min; Jun Haeng Lee; Eun Ran Kim; Chang Ohk Sung; Joo Young Cho; Soo Won Seo; Jae J Kim Journal: Dig Dis Sci Date: 2013-01-24 Impact factor: 3.199