Literature DB >> 14745075

Low androgenization index in elderly women and elderly men with Alzheimer's disease.

A M Paoletti1, S Congia, S Lello, D Tedde, M Orrù, M Pistis, M Pilloni, P Zedda, A Loddo, G B Melis.   

Abstract

The authors investigated whether testosterone levels and testosterone availability differ between older lean subjects with and without Alzheimer's disease (AD). Sex hormone binding globulin (SHBG) and estradiol levels were higher, whereas the free androgenization index (FAI) was lower, in lean subjects with AD than in lean subjects without AD. Factors involved in the increase of SHBG secretion could have an important role in the lower testosterone availability of subjects with AD.

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Year:  2004        PMID： 14745075     DOI： 10.1212/01.wnl.0000094199.60829.f5

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  35 in total

Review 1.  Androgens, aging, and Alzheimer's disease.

Authors:  Christian J Pike; Emily R Rosario; Thuy-Vi V Nguyen
Journal:  Endocrine       Date:  2006-04       Impact factor: 3.633

2.  Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease.

Authors:  Emily R Rosario; Lilly Chang; Elizabeth H Head; Frank Z Stanczyk; Christian J Pike
Journal:  Neurobiol Aging       Date:  2009-05-09       Impact factor: 4.673

Review 3.  Protective actions of sex steroid hormones in Alzheimer's disease.

Authors:  Christian J Pike; Jenna C Carroll; Emily R Rosario; Anna M Barron
Journal:  Front Neuroendocrinol       Date:  2009-05-07       Impact factor: 8.606

Review 4.  Estrogen: a master regulator of bioenergetic systems in the brain and body.

Authors:  Jamaica R Rettberg; Jia Yao; Roberta Diaz Brinton
Journal:  Front Neuroendocrinol       Date:  2013-08-29       Impact factor: 8.606

Review 5.  Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels.

Authors:  Ronald S Swerdloff; Robert E Dudley; Stephanie T Page; Christina Wang; Wael A Salameh
Journal:  Endocr Rev       Date:  2017-06-01       Impact factor: 19.871

6.  Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome.

Authors:  Constance Chace; Deborah Pang; Catherine Weng; Alexis Temkin; Simon Lax; Wayne Silverman; Warren Zigman; Michel Ferin; Joseph H Lee; Benjamin Tycko; Nicole Schupf
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

7.  Interaction of APOE genotype and testosterone on episodic memory in middle-aged men.

Authors:  Matthew S Panizzon; Richard Hauger; Hong Xian; Eero Vuoksimaa; Kelly M Spoon; Sally P Mendoza; Kristen C Jacobson; Terrie Vasilopoulos; Brinda K Rana; Ruth McKenzie; Jeanne M McCaffery; Michael J Lyons; William S Kremen; Carol E Franz
Journal:  Neurobiol Aging       Date:  2013-12-27       Impact factor: 4.673

8.  Thyroid hormones are associated with poorer cognition in mild cognitive impairment.

Authors:  Patrick Quinlan; Arto Nordlund; Karin Lind; Deborah Gustafson; Ake Edman; Anders Wallin
Journal:  Dement Geriatr Cogn Disord       Date:  2010-08-26       Impact factor: 2.959

9.  Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits.

Authors:  Kathryn J Bryan; Joseph C Mudd; Sandy L Richardson; Jaewon Chang; Hyoung-Gon Lee; Xiongwei Zhu; Mark A Smith; Gemma Casadesus
Journal:  J Neurochem       Date:  2009-11-24       Impact factor: 5.372

Review 10.  The many faces of testosterone.

Authors:  Jerald Bain
Journal:  Clin Interv Aging       Date:  2007       Impact factor: 4.458
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