| Literature DB >> 14744755 |
Stanford L Peng1, Michael J Townsend, Jonathan L Hecht, Ian A White, Laurie H Glimcher.
Abstract
The local progression of primary tumors is extrinsically controlled by type 1 immune responses, particularly via the cytokine IFN-gamma, whose secretion is highly dependent on helper T cells. The T-box transcription factor T-bet (Tbx21) plays a critical role in the development of type 1 helper T cells and is essential for the production of IFN-gamma. Here, the T-bet pathway in the autochthonous transgenic adenocarcinoma mouse prostate model is demonstrated to have only a modest effect on the characteristics of primary prostate cancers but rather exerts a significant suppressor function in the development of metastatic disease.Entities:
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Year: 2004 PMID： 14744755 DOI： 10.1158/0008-5472.can-03-3401
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701