OBJECTIVE: To examine the location of deep brain stimulation (DBS) electrode somatosensory evoked potentials (SEPs) and determine the generators of the median nerve SEPs recorded in thalamus and subthalamic nucleus (STN). METHODS: SEPs were recorded from contacts of DBS electrodes and microelectrodes in thalamus and STN to establish the latencies of N13, N18 and N20 in 24 patients (8 tremor, 4 chronic pain, 12 Parkinson disease) undergoing chronic DBS. RESULTS: A large SEP with a mean latency of 17.9+/-1.7 ms was recorded from thalamic contacts. Phase reversal occurred at the horizontal level of the anterior commissure-posterior commissure line. Smaller potentials with similar latency but no reversal could be recorded from STN electrodes. CONCLUSIONS: We propose that the thalamic SEP is generated by excitatory post-synaptic potentials in sensory relay neurons in nucleus ventrocaudalis. A small potential in STN at a similar latency, may be due to volume conduction from thalamus. Intraoperative and postoperative SEP recordings from DBS electrodes could be used to determine the optimal position of the contacts relative to the sensory pathways and the choice of contacts for chronic stimulation.
OBJECTIVE: To examine the location of deep brain stimulation (DBS) electrode somatosensory evoked potentials (SEPs) and determine the generators of the median nerve SEPs recorded in thalamus and subthalamic nucleus (STN). METHODS: SEPs were recorded from contacts of DBS electrodes and microelectrodes in thalamus and STN to establish the latencies of N13, N18 and N20 in 24 patients (8 tremor, 4 chronic pain, 12 Parkinson disease) undergoing chronic DBS. RESULTS: A large SEP with a mean latency of 17.9+/-1.7 ms was recorded from thalamic contacts. Phase reversal occurred at the horizontal level of the anterior commissure-posterior commissure line. Smaller potentials with similar latency but no reversal could be recorded from STN electrodes. CONCLUSIONS: We propose that the thalamic SEP is generated by excitatory post-synaptic potentials in sensory relay neurons in nucleus ventrocaudalis. A small potential in STN at a similar latency, may be due to volume conduction from thalamus. Intraoperative and postoperative SEP recordings from DBS electrodes could be used to determine the optimal position of the contacts relative to the sensory pathways and the choice of contacts for chronic stimulation.
Authors: Eduard Minks; Pavel Jurák; Jan Chládek; Jan Chrastina; Josef Halámek; Daniel J Shaw; Martin Bareš Journal: J Neural Transm (Vienna) Date: 2014-05-09 Impact factor: 3.575
Authors: Carlos Trenado; Saskia Elben; Lena Friggemann; Sonja Gruhn; Stefan Jun Groiss; Jan Vesper; Alfons Schnitzler; Lars Wojtecki Journal: PLoS One Date: 2017-01-12 Impact factor: 3.240
Authors: Jai Y Yu; Apoorva Rajagopal; Judy Syrkin-Nikolau; Sooyoon Shin; Kathryn H Rosenbluth; Dhira Khosla; Erika K Ross; Scott L Delp Journal: Front Neurosci Date: 2020-11-12 Impact factor: 4.677
Authors: Stuart H Isaacson; Elizabeth Peckham; Winona Tse; Olga Waln; Christopher Way; Melita T Petrossian; Nabila Dahodwala; Michael J Soileau; Mark Lew; Cameron Dietiker; Nijee Luthra; Pinky Agarwal; Rohit Dhall; John Morgan; Nicole Calakos; Theresa A Zesiewicz; Ejaz A Shamim; Rajeev Kumar; Peter LeWitt; Holly A Shill; Adam Simmons; Fernando L Pagan; Pravin Khemani; Jessica Tate; Brian Maddux; Lan Luo; William Ondo; Mark Hallett; Apoorva Rajagopal; Paula Chidester; Kathryn H Rosenbluth; Scott L Delp; Rajesh Pahwa Journal: Tremor Other Hyperkinet Mov (N Y) Date: 2020-08-14