Literature DB >> 14744105

Small open reading frames in 5' untranslated regions of mRnas.

Riu Yamashita1, Yutaka Suzuki, Kenta Nakai, Sumio Sugano.   

Abstract

Using the 5'-end sequence data from 'oligo-capped' cDNAs, we generated a representative full-length cDNA dataset for 4870 RefSeq entries, and analyzed the 5' untranslated region (UTR) of these genes. To our surprise, about half of the 4870 genes had an upstream ATG before the ATG that starts the longest open reading frame (ORF), suggesting that about half of them have small ORFs in their 5' UTR of average length of 31 amino acids. They require attention for further analysis to identify their biological role.

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Year:  2003        PMID： 14744105     DOI： 10.1016/j.crvi.2003.09.028

Source DB:  PubMed          Journal:  C R Biol        ISSN： 1631-0691            Impact factor:   1.583


  12 in total

1.  Analysis of small human proteins reveals the translation of upstream open reading frames of mRNAs.

Authors:  Masaaki Oyama; Chiharu Itagaki; Hiroko Hata; Yutaka Suzuki; Tomonori Izumi; Tohru Natsume; Toshiaki Isobe; Sumio Sugano
Journal:  Genome Res       Date:  2004-10       Impact factor: 9.043

2.  Close spacing of AUG initiation codons confers dicistronic character on a eukaryotic mRNA.

Authors:  Daiki Matsuda; Theo W Dreher
Journal:  RNA       Date:  2006-05-08       Impact factor: 4.942

3.  Monocistronic mRNAs containing defective hepatitis C virus-like picornavirus internal ribosome entry site elements in their 5' untranslated regions are efficiently translated in cells by a cap-dependent mechanism.

Authors:  Graham J Belsham; Inge Nielsen; Preben Normann; Elizabeth Royall; Lisa O Roberts
Journal:  RNA       Date:  2008-06-20       Impact factor: 4.942

Review 4.  Emerging evidence for functional peptides encoded by short open reading frames.

Authors:  Shea J Andrews; Joseph A Rothnagel
Journal:  Nat Rev Genet       Date:  2014-02-11       Impact factor: 53.242

5.  Efficient translation initiation directed by the 900-nucleotide-long and GC-rich 5' untranslated region of the human retrotransposon LINE-1 mRNA is strictly cap dependent rather than internal ribosome entry site mediated.

Authors:  Sergey E Dmitriev; Dmitri E Andreev; Ilya M Terenin; Ivan A Olovnikov; Vladimir S Prassolov; William C Merrick; Ivan N Shatsky
Journal:  Mol Cell Biol       Date:  2007-04-30       Impact factor: 4.272

6.  eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.

Authors:  An N Dang Do; Scot R Kimball; Douglas R Cavener; Leonard S Jefferson
Journal:  Physiol Genomics       Date:  2009-06-09       Impact factor: 3.107

7.  Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides.

Authors:  Mark L Crowe; Xue-Qing Wang; Joseph A Rothnagel
Journal:  BMC Genomics       Date:  2006-01-26       Impact factor: 3.969

8.  uPEPperoni: an online tool for upstream open reading frame location and analysis of transcript conservation.

Authors:  Adam Skarshewski; Mitchell Stanton-Cook; Thomas Huber; Sumaya Al Mansoori; Ross Smith; Scott A Beatson; Joseph A Rothnagel
Journal:  BMC Bioinformatics       Date:  2014-02-01       Impact factor: 3.169

9.  Autogenous translational regulation of the Borna disease virus negative control factor X from polycistronic mRNA using host RNA helicases.

Authors:  Yohei Watanabe; Naohiro Ohtaki; Yohei Hayashi; Kazuyoshi Ikuta; Keizo Tomonaga
Journal:  PLoS Pathog       Date:  2009-11-06       Impact factor: 6.823

10.  Whole human genome proteogenomic mapping for ENCODE cell line data: identifying protein-coding regions.

Authors:  Jainab Khatun; Yanbao Yu; John A Wrobel; Brian A Risk; Harsha P Gunawardena; Ashley Secrest; Wendy J Spitzer; Ling Xie; Li Wang; Xian Chen; Morgan C Giddings
Journal:  BMC Genomics       Date:  2013-02-28       Impact factor: 3.969
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