| Literature DB >> 14744104 |
Noboru Jo Sakabe1, Jorge E S de Souza, Pedro A F Galante, Paulo S L de Oliveira, Fábio Passetti, Helena Brentani, Elisson C Osório, André C Zaiats, Maarten R Leerkes, João Paulo Kitajima, Ricardo R Brentani, Robert L Strausberg, Andrew J G Simpson, Sandro José de Souza.
Abstract
A significant fraction of the variability found in the human transcriptome is due to alternative splicing, including alternative exon usage (AEU), intron retention and use of cryptic splice sites. We present a comparison of a large-scale analysis of AEU in the human transcriptome through genome mapping of Open Reading Frame ESTs (ORESTES) and conventional ESTs. It is shown here that ORESTES probe low abundant messages more efficiently. In addition, most of the variants detected by ORESTES affect the structure of the corresponding proteins.Entities:
Mesh：
Year: 2003 PMID： 14744104 DOI： 10.1016/j.crvi.2003.09.027
Source DB: PubMed Journal: C R Biol ISSN： 1631-0691 Impact factor: 1.583