Cheng-shuo Wang1, Zhen Dong. 1. Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun 130031, China.
Abstract
OBJECTIVE: To understand the expression of Toll-like receptor-2 (TLR-2) and Toll-like receptor-4 (TLR-4) in epithelial cell of nasal mucosa, and to investigate the role of Toll-like receptors in the innate immunity of nasal mucosa. METHODS: Specimens from 30 patients with chronic sinusitis and 21 healthy adults were examined by in situ hybridization for TLR-2 and TLR-4 mRNA. RESULTS: All 30, samples of chronic sinusitis showed a stranger expression of TLR-2 and TLR-4 than in controls (t = 8.605, P < 0.0005, t = 9.050, P < 0.0005). CONCLUSION: It is suggested that epithelial in nasal mucosa were not just a physical barrier, which could represent a novel defense mechanism of the host during bacterial infections through Toll-like receptors.
OBJECTIVE: To understand the expression of Toll-like receptor-2 (TLR-2) and Toll-like receptor-4 (TLR-4) in epithelial cell of nasal mucosa, and to investigate the role of Toll-like receptors in the innate immunity of nasal mucosa. METHODS: Specimens from 30 patients with chronic sinusitis and 21 healthy adults were examined by in situ hybridization for TLR-2 and TLR-4 mRNA. RESULTS: All 30, samples of chronic sinusitis showed a stranger expression of TLR-2 and TLR-4 than in controls (t = 8.605, P < 0.0005, t = 9.050, P < 0.0005). CONCLUSION: It is suggested that epithelial in nasal mucosa were not just a physical barrier, which could represent a novel defense mechanism of the host during bacterial infections through Toll-like receptors.