Disseminated intravascular coagulation: diagnosis, treatment and related pathophysiology.

This review presents a current evaluation of disseminated intravascular coagulopathy from approaches involving clinical and differential diagnosis, pharmacological treatment, biological markers, disease effects on various organs, risk factors and related pathophysiological conditions. While the optimal regimens for treatment with blood components and the absolute indications for anticoagulant and antifibrinolytic treatments are unknown, various studies are discussed which offer promising new drugs for the present and the future. Associations between this disease and other pathophysiologies are presented which provoke new perspective and insight into disease occurrence and progression.