Uzma Samadani1, Kevin D Judy. 1. Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA. uzmasam@yahoo.com
Abstract
BACKGROUND/AIMS: A meta-analysis of thirteen studies performing stereotactic biopsy of brainstem lesions is combined with our recent series of 12 patients with brainstem lesions comparing MRI findings to biopsy histopathology to determine whether these lesions could have been diagnosed radiographically. METHODS: 12 consecutive stereotactic biopsies and literature analysis were performed to analyze clinical, radiographic and histopathologic data. RESULTS: Stereotactic biopsy of lesions in the brainstem was in 96% diagnostic. There was one mortality (3% of cases) and 4% morbidity associated with the procedure. Pathology showed that half of the adult brainstem intrinsic lesions were gliomas, 10% were metastases, and the remainder were hematomas, vascular malformations, lymphomas, demyelination, cysts, radiation necrosis, abscesses, vasculitis, infarcts, leukemia, cryptococcus, or granulomas. CONCLUSIONS: Empiric treatment of adult brainstem lesions is not prudent because there is a wide spectrum of diverse pathology in this location. Stereotactic biopsy is a safe and effective method for determining histopathology. Copyright 2003 S. Karger AG, Basel
BACKGROUND/AIMS: A meta-analysis of thirteen studies performing stereotactic biopsy of brainstem lesions is combined with our recent series of 12 patients with brainstem lesions comparing MRI findings to biopsy histopathology to determine whether these lesions could have been diagnosed radiographically. METHODS: 12 consecutive stereotactic biopsies and literature analysis were performed to analyze clinical, radiographic and histopathologic data. RESULTS: Stereotactic biopsy of lesions in the brainstem was in 96% diagnostic. There was one mortality (3% of cases) and 4% morbidity associated with the procedure. Pathology showed that half of the adult brainstem intrinsic lesions were gliomas, 10% were metastases, and the remainder were hematomas, vascular malformations, lymphomas, demyelination, cysts, radiation necrosis, abscesses, vasculitis, infarcts, leukemia, cryptococcus, or granulomas. CONCLUSIONS: Empiric treatment of adult brainstem lesions is not prudent because there is a wide spectrum of diverse pathology in this location. Stereotactic biopsy is a safe and effective method for determining histopathology. Copyright 2003 S. Karger AG, Basel
Authors: Stephanie Puget; Kevin Beccaria; Thomas Blauwblomme; Thomas Roujeau; Syril James; Jacques Grill; Michel Zerah; Pascale Varlet; Christian Sainte-Rose Journal: Childs Nerv Syst Date: 2015-09-09 Impact factor: 1.475
Authors: Ik Lin Tan; Ellen M Mowry; Sonya U Steele; Carlos A Pardo; Justin C McArthur; Avindra Nath; Arun Venkatesan Journal: J Neurol Date: 2013-06-09 Impact factor: 4.849
Authors: N Manoj; A Arivazhagan; D I Bhat; H R Arvinda; A Mahadevan; V Santosh; B Indira Devi; S Sampath; B A Chandramouli Journal: J Neurosci Rural Pract Date: 2014-01