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Literature DB >> 14742233

Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.

Li Huang¹, Xiong Yuan, Christopher Aiken, Chin Ho Chen.

Abstract

A class of betulinic acid derivatives was synthesized to target two critical steps in the human immunodeficiency virus type 1 (HIV-1) replication cycle, entry and maturation. Each mechanism of HIV-1 inhibition is distinct from clinically available anti-HIV therapeutics. The viral determinants of the antientry and antimaturation activities are the bridging sheet of HIV-1 gp120 and the P24/p2 cleavage site, respectively.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2004 PMID： 14742233 PMCID： PMC321552 DOI： 10.1128/AAC.48.2.663-665.2004

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

1. The role of the third beta strand in gp120 conformation and neutralization sensitivity of the HIV-1 primary isolate DH012.

Authors: C B Zhu; L Zhu; S Holz-Smith; T J Matthews; C H Chen
Journal: Proc Natl Acad Sci U S A Date: 2001-12-04 Impact factor: 11.205

Review 2. Molecular targets of anti-HIV-1 triterpenes.

Authors: Li Huang; Chin Ho Chen
Journal: Curr Drug Targets Infect Disord Date: 2002-03

3. Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.

Authors: I-Chen Sun; Chin-Ho Chen; Yoshiki Kashiwada; Jiu-Hong Wu; Hui-Kang Wang; Kuo-Hsiung Lee
Journal: J Med Chem Date: 2002-09-12 Impact factor: 7.446

4. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1.

Authors: H G Göttlinger; J G Sodroski; W A Haseltine
Journal: Proc Natl Acad Sci U S A Date: 1989-08 Impact factor: 11.205

5. Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturation.

Authors: T Kanamoto; Y Kashiwada; K Kanbara; K Gotoh; M Yoshimori; T Goto; K Sano; H Nakashima
Journal: Antimicrob Agents Chemother Date: 2001-04 Impact factor: 5.191

6. Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particles.

Authors: D J Wyma; A Kotov; C Aiken
Journal: J Virol Date: 2000-10 Impact factor: 5.103

7. Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564.

Authors: S L Holz-Smith; I C Sun; L Jin; T J Matthews; K H Lee; C H Chen
Journal: Antimicrob Agents Chemother Date: 2001-01 Impact factor: 5.191

8. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors.

Authors: J H Condra; W A Schleif; O M Blahy; L J Gabryelski; D J Graham; J C Quintero; A Rhodes; H L Robbins; E Roth; M Shivaprakash
Journal: Nature Date: 1995-04-06 Impact factor: 49.962

9. Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro.

Authors: B A Larder; P Kellam; S D Kemp
Journal: Nature Date: 1993-09-30 Impact factor: 49.962

10. The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity.

Authors: H G Kräusslich; M Fäcke; A M Heuser; J Konvalinka; H Zentgraf
Journal: J Virol Date: 1995-06 Impact factor: 5.103

13 in total

1. Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.

Authors: Donglei Yu; Yojiro Sakurai; Chin-Ho Chen; Fang-Rong Chang; Li Huang; Yoshiki Kashiwada; Kuo-Hsiung Lee
Journal: J Med Chem Date: 2006-09-07 Impact factor: 7.446

2. Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41.

Authors: Kun Liu; Hong Lu; Ling Hou; Zhi Qi; Cátia Teixeira; Florent Barbault; Bo-Tao Fan; Shuwen Liu; Shibo Jiang; Lan Xie
Journal: J Med Chem Date: 2008-12-25 Impact factor: 7.446

3. Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.

Authors: Zhao Dang; Keduo Qian; Phong Ho; Lei Zhu; Kuo-Hsiung Lee; Li Huang; Chin-Ho Chen
Journal: Bioorg Med Chem Lett Date: 2012-07-03 Impact factor: 2.823

4. Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors.

Authors: Zhao Dang; Lei Zhu; Weihong Lai; Hal Bogerd; Kuo-Hsiung Lee; Li Huang; Chin-Ho Chen
Journal: ACS Med Chem Lett Date: 2016-01-09 Impact factor: 4.345

5. New betulinic acid derivatives as potent proteasome inhibitors.

Authors: Keduo Qian; Sang-Yong Kim; Hsin-Yi Hung; Li Huang; Chin-Ho Chen; Kuo-Hsiung Lee
Journal: Bioorg Med Chem Lett Date: 2011-07-26 Impact factor: 2.823

Review 6. Structure and Anti-HIV Activity of Betulinic Acid Analogues.

Authors: Qiu-Xia Huang; Hong-Fei Chen; Xing-Rui Luo; Yin-Xiang Zhang; Xu Yao; Xing Zheng
Journal: Curr Med Sci Date: 2018-06-22

Review 7. Proteasome regulators: activators and inhibitors.

Authors: Li Huang; Chin Ho Chen
Journal: Curr Med Chem Date: 2009 Impact factor: 4.530

8. Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.

Authors: Keduo Qian; Donglei Yu; Chin-Ho Chen; Li Huang; Susan L Morris-Natschke; Theodore J Nitz; Karl Salzwedel; Mary Reddick; Graham P Allaway; Kuo-Hsiung Lee
Journal: J Med Chem Date: 2009-05-28 Impact factor: 7.446

9. Structure Optimization of Aloperine Derivatives as HIV-1 Entry Inhibitors.

Authors: Zhao Dang; Hua Xie; Lei Zhu; Qingye Zhang; Zhijun Li; Li Huang; Chin-Ho Chen
Journal: ACS Med Chem Lett Date: 2017-10-09 Impact factor: 4.345

10. Activation and inhibition of the proteasome by betulinic acid and its derivatives.

Authors: Li Huang; Phong Ho; Chin-Ho Chen
Journal: FEBS Lett Date: 2007-09-24 Impact factor: 4.124