Literature DB >> 14742224

Differential diffusions of indinavir and lopinavir in genital secretions of human immunodeficiency virus-infected women.

Odile Launay1, Michel Tod, Kamel Louchahi, Linda Belarbi, Olivier Bouchaud, Nathalie Mémain, Olivier Petitjean, Michel Robineau, Loïc Guillevin, Olivier Lortholary.   

Abstract

Plasma and cervicovaginal secretion (CVS) samples were collected from 19 human immunodeficiency virus type 1-infected women on lopinavir- or indinavir-containing regimens. Lopinavir and indinavir were detectable in 29 and 93% of CVS samples, respectively, a finding that may be ascribed to these drugs' differences in protein binding and pK(a). The relationship between lopinavir and indinavir pharmacodynamics and viral evolution in the female genital tract should be assessed over time.

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Year:  2004        PMID： 14742224      PMCID： PMC321543          DOI： 10.1128/AAC.48.2.632-634.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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