| Literature DB >> 14741714 |
Masashi Ohtsuka1, Hiroyuki Takano, Masashi Suzuki, Yunzeng Zou, Hiroshi Akazawa, Masaji Tamagawa, Koji Wakimoto, Haruaki Nakaya, Issei Komuro.
Abstract
We used Na(+)-Ca(2+) exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mice hearts after ischemia/reperfusion and the infarct size was significantly small in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury.Entities:
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Year: 2004 PMID： 14741714 DOI： 10.1016/j.bbrc.2003.12.165
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575