| Literature DB >> 14741427 |
Yuekui Li1, Ling Liu, Dongge Liu, S Woodward, Steven W Barger, Robert E Mrak, W Sue T Griffin.
Abstract
The fate of the fragmented DNA (fDNA) observed in neuronal nuclei in Alzheimer brain is unknown. However, its fate is suggested as fDNA is found in the cytoplasm of adjacent activated microglia. After a brief incubation with fDNA, approximately 70% of microglia had fDNA in their cytoplasm, were activated, and overexpressed interleukin-1beta. Microglial activation enhanced uptake whereas blocking scavenger receptors suppressed this uptake. These results suggest that the brain rids itself of fDNA from dying neurons through microglial uptake, activation, and overexpression of IL-1. Such overexpression of IL-1 in Alzheimer brain has been linked to Alzheimer pathogenesis.Entities:
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Year: 2004 PMID： 14741427 PMCID： PMC3846353 DOI： 10.1016/j.jneuroim.2003.10.043
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478