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Literature DB >> 14741382

Induction of p53-independent apoptosis by the BH3-only protein ITM2Bs.

Abstract

The p53 tumor suppressor protein is critically involved in cell cycle regulation and programmed cell death. Here we show that expression of the BH3-only protein ITM2Bs is able to induce apoptotic cell death in p53+/+, as well as in p53-/- cell lines. This cell death involves neither subcellular redistribution of p53 nor transcriptional regulation of p53 target genes such as Bax, Ras, Puma or Bcl-2. Together, our data provide evidence for a p53-independent apoptotic role of ITM2Bs.

Entities: Disease Gene

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Year: 2004 PMID： 14741382 DOI： 10.1016/s0014-5793(03)01519-9

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

14 in total

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Authors: Maria Tsachaki; Despina Serlidaki; Andriana Fetani; Vasiliki Zarkou; Ismini Rozani; Jorge Ghiso; Spiros Efthimiopoulos
Journal: Glycobiology Date: 2011-07-13 Impact factor: 4.313

2. Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma.

Authors: David Creytens; Joost van Gorp; Suvi Savola; Liesbeth Ferdinande; Thomas Mentzel; Louis Libbrecht
Journal: Virchows Arch Date: 2014-07 Impact factor: 4.064

Induction of p53-independent apoptosis by the BH3-only protein ITM2Bs.

1. Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.

2. Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma.

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5. BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells.

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8. Ras puts the brake on doxorubicin-mediated cell death in p53-expressing cells.

9. A custom rat and baboon hypertension gene array to compare experimental models.

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