| Literature DB >> 14741291 |
Laval Chan1, Sanjoy K Das, T Jagadeeswar Reddy, Carl Poisson, Mélanie Proulx, Oswy Pereira, Marc Courchesne, Caroline Roy, Wuyi Wang, Arshad Siddiqui, Constantin G Yannopoulos, Nghe Nguyen-Ba, Denis Labrecque, Richard Bethell, Martine Hamel, Philippe Courtemanche-Asselin, Lucille L'Heureux, Maud David, Olivier Nicolas, Stéphanie Brunette, Darius Bilimoria, Jean Bédard.
Abstract
The discovery of a novel class of HCV NS5B polymerase inhibitors, 3-arylsulfonylamino-5-phenyl-thiophene-2-carboxylic acids is described. SAR studies have yielded several potent inhibitors of HCV polymerase as well as of HCV subgenomic RNA replication in Huh-7 cells.Entities:
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Year: 2004 PMID： 14741291 DOI： 10.1016/j.bmcl.2003.10.067
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823