| Literature DB >> 14741280 |
C Yoakim1, P R Bonneau, R Déziel, L Doyon, J Duan, I Guse, S Landry, E Malenfant, J Naud, W W Ogilvie, J A O'Meara, R Plante, B Simoneau, B Thavonekham, M Bös, M G Cordingley.
Abstract
A series of 8-heteroarylthiomethyldipyridodiazepinone derivatives were prepared and evaluated for their antiviral profile against wild type virus and the important K103N/Y181C mutant as an indicator for broad activity. 2,6-Dimethylpyridine derivative 16 was found to have a good pharmacokinetic profile in spite of poor metabolic stability in rat liver microsomes.Entities:
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Year: 2004 PMID： 14741280 DOI： 10.1016/j.bmcl.2003.11.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823