Literature DB >> 14741279

Vancomycin disulfide derivatives as antibacterial agents.

YongQi Mu1, Matthew Nodwell, John L Pace, Jeng Pyng Shaw, J Kevin Judice.   

Abstract

A series of lipidated vancomycin analogues 1 bearing disulfide bonds within their lipid chains was designed and synthesized to optimize their ADME profiles while retaining antibacterial potency. These compounds exhibited good activity against resistant organisms and low accumulation in tissues such as kidney and liver.

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Year:  2004        PMID： 14741279     DOI： 10.1016/j.bmcl.2003.11.040

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Tackling vancomycin-resistant bacteria with 'lipophilic-vancomycin-carbohydrate conjugates'.

Authors:  Venkateswarlu Yarlagadda; Mohini M Konai; Goutham B Manjunath; Chandradhish Ghosh; Jayanta Haldar
Journal:  J Antibiot (Tokyo)       Date:  2014-10-29       Impact factor: 2.649

2.  Thiol- and Disulfide-Containing Vancomycin Derivatives Against Bacterial Resistance and Biofilm Formation.

Authors:  Inga S Shchelik; Karl Gademann
Journal:  ACS Med Chem Lett       Date:  2021-10-18       Impact factor: 4.345

3.  Bis[3α,7α,12α-tris-(4-nitro-benzo-yloxy)-5β-cholan-24-yl] disulfide-ethyl acetate-n-hexane (4/4/1).

Authors:  Krzysztof Brzezinski; Aneta M Tomkiel; Zenon Lotowski; Jacek Morzycki; Zbigniew Dauter
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-12-11

4.  tBuOK-triggered bond formation reactions.

Authors:  Yulong Xu; Xiaonan Shi; Lipeng Wu
Journal:  RSC Adv       Date:  2019-08-02       Impact factor: 3.361

5.  Convenient and efficient synthesis of functionalized unsymmetrical Z-alkenyl disulfanes.

Authors:  M Musiejuk; J Doroszuk; D Witt
Journal:  RSC Adv       Date:  2018-03-07       Impact factor: 3.361

Review 6.  Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014-2022.

Authors:  Emma van Groesen; Paolo Innocenti; Nathaniel I Martin
Journal:  ACS Infect Dis       Date:  2022-07-27       Impact factor: 5.578

7.  Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index.

Authors:  Nigam M Mishra; Izabela Stolarzewicz; David Cannaerts; Joris Schuermans; Rob Lavigne; Yannick Looz; Bart Landuyt; Liliane Schoofs; Dominique Schols; Jan Paeshuyse; Peter Hickenbotham; Martha Clokie; Walter Luyten; Erik V Van der Eycken; Yves Briers
Journal:  Front Microbiol       Date:  2018-06-07       Impact factor: 5.640

8.  Phosphorus-Sulfur Heterocycles Incorporating an O-P(S)-O or O-P(S)-S-S-P(S)-O Scaffold: One-Pot Synthesis and Crystal Structure Study.

Authors:  Guoxiong Hua; Kate Davidson; David B Cordes; Junyi Du; Alexandra M Z Slawin; J Derek Woollins
Journal:  Molecules       Date:  2017-10-10       Impact factor: 4.411
  8 in total

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