Literature DB >> 14741269

Peptidyl aldehydes as slow-binding inhibitors of dual-specificity phosphatases.

Junguk Park1, Hua Fu, Dehua Pei.   

Abstract

Peptidyl aldehydes were tested for inhibition of dual-specificity phosphatases VH1 and VHR. The most potent compound, cinnamaldehyde-Gly-Glu-Glu (Cinn-GEE), acted as a slow-binding inhibitor with K(I)* values of 18 and 288 microM against VH1 and VHR, respectively.

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Year:  2004        PMID： 14741269     DOI： 10.1016/j.bmcl.2003.11.027

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Analyses of lysine aldehyde cross-linking in collagen reveal that the mature cross-link histidinohydroxylysinonorleucine is an artifact.

Authors:  David R Eyre; MaryAnn Weis; Jyoti Rai
Journal:  J Biol Chem       Date:  2019-02-07       Impact factor: 5.157

2.  Trapping conformational states along ligand-binding dynamics of peptide deformylase: the impact of induced fit on enzyme catalysis.

Authors:  Sonia Fieulaine; Adrien Boularot; Isabelle Artaud; Michel Desmadril; Frédéric Dardel; Thierry Meinnel; Carmela Giglione
Journal:  PLoS Biol       Date:  2011-05-24       Impact factor: 8.029
  2 in total

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