| Literature DB >> 14739547 |
Andrew McCaddon1, Kaj Blennow, Peter Hudson, Alan Hughes, Joan Barber, Rob Gray, Gareth Davies, John H H Williams, Jennifer Duguid, Alwyn Lloyd, Steve Tandy, Marge Everall, Howard Cattell, Anne McCaddon, Dick Ellis, Mona Palmer, Nenad Bogdanovic, Carl-Gerhard Gottfries, Henrik Zetterberg, Lars Rymo, Björn Regland.
Abstract
Isoforms of the vitamin B(12) carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer's disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed AD and 74 healthy elderly controls. TC 776C>G polymorphism was also determined for 94 histopathologically confirmed AD patients and 107 controls. Serum holo-TC levels were significantly higher in TC 776C homozygotes (p = 0.04). Kaplan-Meier survival functions differed between homozygous genotypes (Cox's F-Test F(42, 46) = 2.1; p = 0.008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study. Copyright 2004 S. Karger AG, BaselEntities:
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Year: 2004 PMID： 14739547 DOI： 10.1159/000076359
Source DB: PubMed Journal: Dement Geriatr Cogn Disord ISSN： 1420-8008 Impact factor: 2.959