Literature DB >> 14739382

Lung cancer and dust exposure: results of a prospective cohort study following 3260 workers for 50 years.

H Moshammer1, M Neuberger.   

Abstract

AIMS: To study the lasting health impact of occupational dust exposure on life expectancy and specific causes of death.
METHODS: Male Viennese workers, selected at age > or =40 (mean 54) years during preventive check-ups between 1950 and 1960, were followed prospectively until death. Half of them (1630) were exposed at work to (non-fibrous) particulates, while the non-exposed workers were matched for year, age, and smoking status at the start of observation.
RESULTS: Average life expectancy of those exposed was 1.6 years less than that of those non-exposed. Only a small part of this decrease in life expectancy (hazards ratios in brackets) was related to acknowledged occupational diseases such as silicosis and silicotuberculosis (67.12). Chronic obstructive lung disease (1.82) and cancer of the lung (1.42) and stomach (1.77) were found more frequently among those exposed.
CONCLUSIONS: Results support the hypothesis that high exposure to insoluble particulates such as silica in the metal, glass, ceramics, and stone industries promotes bronchial cancer and chronic obstructive pulmonary disease. The finding of an increased incidence of stomach cancer might be related to particles swallowed after clearance from the airways.

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Year:  2004        PMID: 14739382      PMCID: PMC1740700          DOI: 10.1136/oem.2002.001255

Source DB:  PubMed          Journal:  Occup Environ Med        ISSN: 1351-0711            Impact factor:   4.402


  12 in total

Review 1.  Occupational respiratory diseases.

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2.  Risk of stomach cancer associated with 12 workplace hazards: analysis of death certificates from 24 states of the United States with the aid of job exposure matrices.

Authors:  P Cocco; M H Ward; M Dosemeci
Journal:  Occup Environ Med       Date:  1999-11       Impact factor: 4.402

3.  Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma; a study of 684 proved cases.

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4.  Cancer and tobacco smoking; a preliminary report.

Authors:  M L LEVIN; H GOLDSTEIN; P R GERHARDT
Journal:  J Am Med Assoc       Date:  1950-05-27

5.  Occupational dust exposure and cancer mortality--results of a prospective cohort study.

Authors:  M Neuberger; M Kundi
Journal:  IARC Sci Publ       Date:  1990

6.  Mineral composition other than quartz is a critical determinant of the particle inflammatory potential.

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7.  A cohort mortality and nested case-control study of French and Austrian talc workers.

Authors:  P Wild; K Leodolter; M Réfrégier; H Schmidt; T Zidek; G Haidinger
Journal:  Occup Environ Med       Date:  2002-02       Impact factor: 4.402

8.  Occupation and gastric cancer in Spain.

Authors:  C A González; M Sanz; G Marcos; S Pita; E Brullet; F Vida; A Agudo; C C Hsieh
Journal:  Scand J Work Environ Health       Date:  1991-08       Impact factor: 5.024

9.  Long-term effect of occupational dust exposure.

Authors:  M Neuberger; G Westphal; P Bauer
Journal:  Sangyo Igaku       Date:  1988-09

10.  Adenocarcinoma of the stomach and exposure to occupational dust.

Authors:  W E Wright; L Bernstein; J M Peters; D H Garabrant; T M Mack
Journal:  Am J Epidemiol       Date:  1988-07       Impact factor: 4.897

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  3 in total

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Authors:  H Moshammer; Manfred Neuberger
Journal:  Int Arch Occup Environ Health       Date:  2008-04-12       Impact factor: 3.015

2.  Enhancing Human Biomonitoring Studies through Linkage to Administrative Registers-Status in Europe.

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Journal:  Int J Environ Res Public Health       Date:  2022-05-06       Impact factor: 3.390

3.  Systematic Review of the Effects of Asbestos Exposure on the Risk of Cancer between Children and Adults.

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  3 in total

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