Literature DB >> 14738975

Synthesis of condensed quinolines and quinazolines as DNA ligands.

Natacha Malecki1, Pascal Carato, Benoît Rigo, Jean-François Goossens, Raymond Houssin, Christian Bailly, Jean-Pierre Hénichart.   

Abstract

Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recognition.

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Year:  2004        PMID： 14738975     DOI： 10.1016/j.bmc.2003.10.014

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.

Authors:  Nikolai M Evdokimov; Severine Van Slambrouck; Petra Heffeter; Lee Tu; Benjamin Le Calvé; Delphine Lamoral-Theys; Carla J Hooten; Pavel Y Uglinskii; Snezna Rogelj; Robert Kiss; Wim F A Steelant; Walter Berger; Jeremy J Yang; Cristian G Bologa; Alexander Kornienko; Igor V Magedov
Journal:  J Med Chem       Date:  2011-03-09       Impact factor: 7.446

2.  A new synthetic route to original sulfonamide derivatives in 2-trichloromethylquinazoline series: a structure-activity relationship study of antiplasmodial activity.

Authors:  Nicolas Primas; Pierre Verhaeghe; Anita Cohen; Charline Kieffer; Aurélien Dumètre; Sébastien Hutter; Sylvain Rault; Pascal Rathelot; Nadine Azas; Patrice Vanelle
Journal:  Molecules       Date:  2012-07-05       Impact factor: 4.411

3.  DFT-based reactivity and combined QSAR, molecular docking of 1,2,4,5-Tetrazine derivatives as inhibitors of Pim-1 kinase.

Authors:  Halima Hazhazi; Nadjib Melkemi; Toufik Salah; Mohammed Bouachrine
Journal:  Heliyon       Date:  2019-09-26

4.  A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions.

Authors:  Shabnam Shaabani; Ahmad Shaabani; Monika Kucerakova; Michal Dusek
Journal:  Front Chem       Date:  2019-09-18       Impact factor: 5.221
  4 in total

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