Literature DB >> 14738759

IL-6 trans-signaling: the heat is on.

Stefan Rose-John1, Markus F Neurath.   

Abstract

The molecular consequence of the fever response has been illuminated by a recent study showing that a temperature shift to 40 degrees C resulted in increased leukocyte adhesion to tissue sections, which was mediated by L-selectin activation in lymphocytes. This L-selectin activation during heat responses was dependent on IL-6 trans-signaling via the soluble IL-6R.

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Year:  2004        PMID： 14738759     DOI： 10.1016/s1074-7613(04)00003-2

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  30 in total

Review 1.  Interleukin-6 in aging and chronic disease: a magnificent pathway.

Authors:  Marcello Maggio; Jack M Guralnik; Dan L Longo; Luigi Ferrucci
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Review 2.  Molecular mechanisms of soluble cytokine receptor generation.

Authors:  Stewart J Levine
Journal:  J Biol Chem       Date:  2008-04-01       Impact factor: 5.157

3.  Influence of humanized anti-IL-6R antibody, tocilizumab on the activity of soluble gp130, natural inhibitor of IL-6 signaling.

Authors:  Misato Hashizume; Masahiko Mihara
Journal:  Rheumatol Int       Date:  2008-09-20       Impact factor: 2.631

4.  Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst.

Authors:  Jun Wang; Qing Wang; Tao Han; Yong-Kui Li; Sheng-Li Zhu; Fang Ao; Jian Feng; Ming-Zhen Jing; Li Wang; Lin-Bai Ye; Ying Zhu
Journal:  Cell Mol Immunol       Date:  2014-09-01       Impact factor: 11.530

5.  Microglia priming by interleukin-6 signaling is enhanced in aged mice.

Authors:  Katherine M Garner; Ravi Amin; Rodney W Johnson; Emily J Scarlett; Michael D Burton
Journal:  J Neuroimmunol       Date:  2018-09-10       Impact factor: 3.478

6.  Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection.

Authors:  Nadine M Lerret; Ting Li; Jiao-Jing Wang; Hee-Kap Kang; Sheng Wang; Xueqiong Wang; Chunfa Jie; Yashpal S Kanwar; Michael M Abecassis; Xunrong Luo; Zheng Zhang
Journal:  J Am Soc Nephrol       Date:  2015-03-18       Impact factor: 10.121

Review 7.  Selected cytokine pathways in rheumatoid arthritis.

Authors:  Mélissa Noack; Pierre Miossec
Journal:  Semin Immunopathol       Date:  2017-02-17       Impact factor: 9.623

8.  The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

Authors:  Aysefa Doganci; Tatjana Eigenbrod; Norbert Krug; George T De Sanctis; Michael Hausding; Veit J Erpenbeck; El-Bdaoui Haddad; Hans A Lehr; Edgar Schmitt; Tobias Bopp; Karl-J Kallen; Udo Herz; Steffen Schmitt; Cornelia Luft; Olaf Hecht; Jens M Hohlfeld; Hiroaki Ito; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Stefan Rose-John; Harald Renz; Markus F Neurath; Peter R Galle; Susetta Finotto
Journal:  J Clin Invest       Date:  2005-02       Impact factor: 14.808

9.  IL-6-trans-signalling increases rapid-eye-movement sleep in rats.

Authors:  Ulrike May; Thomas Schiffelholz; Paul Christian Baier; James M Krueger; Stefan Rose-John; Jürgen Scheller
Journal:  Eur J Pharmacol       Date:  2009-04-19       Impact factor: 4.432

10.  CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.

Authors:  Chunyan Zhang; Hong Xin; Wang Zhang; Paul J Yazaki; Zhifang Zhang; Keith Le; Wenzhao Li; Heehyoung Lee; Larry Kwak; Stephen Forman; Richard Jove; Hua Yu
Journal:  Immunity       Date:  2016-04-19       Impact factor: 31.745
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