PURPOSE: Glaucomatous neuropathy is a type of cell death by apoptosis. Apoptosis is a genetically controlled form of cell death, and one of its primary regulatory steps is the activation of the tumour suppressor protein p53, of which p21 is an effector protein. The association between p21 codon 31 polymorphism and primary open-angle glaucoma (POAG) patients was evaluated in this study. METHODS: The study included 58 POAG patients and a control group of 59 healthy volunteers. Polymerase chain reaction-based analysis was used to resolve the p21 codon 31 polymorphism. RESULTS: The genotype frequencies of p21 codon 31 polymorphism were statistically different (p < 0.05) between the two groups. The Arg allele of the p21 codon 31 polymorphism was more frequently found in POAG patients than in healthy individuals (odds ratio: 2.389, 95% confidence interval: 1.14-5.01). CONCLUSION: This study suggests that an association exists between the Arg allele of the p21 codon 31 polymorphism and POAG in the Chinese population.
PURPOSE:Glaucomatous neuropathy is a type of cell death by apoptosis. Apoptosis is a genetically controlled form of cell death, and one of its primary regulatory steps is the activation of the tumour suppressor protein p53, of which p21 is an effector protein. The association between p21 codon 31 polymorphism and primary open-angle glaucoma (POAG) patients was evaluated in this study. METHODS: The study included 58 POAG patients and a control group of 59 healthy volunteers. Polymerase chain reaction-based analysis was used to resolve the p21 codon 31 polymorphism. RESULTS: The genotype frequencies of p21 codon 31 polymorphism were statistically different (p < 0.05) between the two groups. The Arg allele of the p21 codon 31 polymorphism was more frequently found in POAG patients than in healthy individuals (odds ratio: 2.389, 95% confidence interval: 1.14-5.01). CONCLUSION: This study suggests that an association exists between the Arg allele of the p21 codon 31 polymorphism and POAG in the Chinese population.
Authors: Henriët Springelkamp; Adriana I Iglesias; Aniket Mishra; René Höhn; Robert Wojciechowski; Anthony P Khawaja; Abhishek Nag; Ya Xing Wang; Jie Jin Wang; Gabriel Cuellar-Partida; Jane Gibson; Jessica N Cooke Bailey; Eranga N Vithana; Puya Gharahkhani; Thibaud Boutin; Wishal D Ramdas; Tanja Zeller; Robert N Luben; Ekaterina Yonova-Doing; Ananth C Viswanathan; Seyhan Yazar; Angela J Cree; Jonathan L Haines; Jia Yu Koh; Emmanuelle Souzeau; James F Wilson; Najaf Amin; Christian Müller; Cristina Venturini; Lisa S Kearns; Jae Hee Kang; Yih Chung Tham; Tiger Zhou; Elisabeth M van Leeuwen; Stefan Nickels; Paul Sanfilippo; Jiemin Liao; Herma van der Linde; Wanting Zhao; Leonieke M E van Koolwijk; Li Zheng; Fernando Rivadeneira; Mani Baskaran; Sven J van der Lee; Shamira Perera; Paulus T V M de Jong; Ben A Oostra; André G Uitterlinden; Qiao Fan; Albert Hofman; E-Shyong Tai; Johannes R Vingerling; Xueling Sim; Roger C W Wolfs; Yik Ying Teo; Hans G Lemij; Chiea Chuen Khor; Rob Willemsen; Karl J Lackner; Tin Aung; Nomdo M Jansonius; Grant Montgomery; Philipp S Wild; Terri L Young; Kathryn P Burdon; Pirro G Hysi; Louis R Pasquale; Tien Yin Wong; Caroline C W Klaver; Alex W Hewitt; Jost B Jonas; Paul Mitchell; Andrew J Lotery; Paul J Foster; Veronique Vitart; Norbert Pfeiffer; Jamie E Craig; David A Mackey; Christopher J Hammond; Janey L Wiggs; Ching-Yu Cheng; Cornelia M van Duijn; Stuart MacGregor Journal: Hum Mol Genet Date: 2017-01-15 Impact factor: 6.150
Authors: Thomas Ressiniotis; Philip G Griffiths; Sharon M Keers; Patrick F Chinnery; Michael Birch Journal: BMC Ophthalmol Date: 2005-04-04 Impact factor: 2.209