Literature DB >> 14738375

Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.

Linda C Meade-Tollin1, E M Kithsiri Wijeratne, Deborah Cooper, Mischa Guild, Edlyn Jon, Anne Fritz, Guang-Xiong Zhou, Luke Whitesell, Jing-Yu Liang, A A Leslie Gunatilaka.   

Abstract

Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at subcytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.

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Year:  2004        PMID： 14738375     DOI： 10.1021/np0304114

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  15 in total

1.  Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues.

Authors:  E M Kithsiri Wijeratne; Bharat P Bashyal; Manping X Liu; Danilo D Rocha; G M Kamal B Gunaherath; Jana M U'Ren; Malkanthi K Gunatilaka; A Elizabeth Arnold; Luke Whitesell; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2012-01-20       Impact factor: 4.050

2.  Cancer Phytotherapy: Recent Views on the Role of Antioxidant and Angiogenesis Activities.

Authors:  Mahmood Bahmani; Hedayatollah Shirzad; Najmeh Shahinfard; Laaleh Sheivandi; Mahmoud Rafieian-Kopaei
Journal:  J Evid Based Complementary Altern Med       Date:  2016-06-22

3.  Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum.

Authors:  Jixun Zhan; Anna M Burns; Manping X Liu; Stanley H Faeth; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2007-02-08       Impact factor: 4.050

4.  Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response.

Authors:  Yu Du; Nicole F Villeneuve; Xiao-Jun Wang; Zheng Sun; Weimin Chen; Jixue Li; Hongxiang Lou; Pak Kin Wong; Donna D Zhang
Journal:  Environ Health Perspect       Date:  2008-09       Impact factor: 9.031

5.  Autophagy triggered by magnolol derivative negatively regulates angiogenesis.

Authors:  S Kumar; S K Guru; A S Pathania; A Kumar; S Bhushan; F Malik
Journal:  Cell Death Dis       Date:  2013-10-31       Impact factor: 8.469

6.  Oridonin induces the apoptosis of metastatic hepatocellular carcinoma cells via a mitochondrial pathway.

Authors:  Min Zhu; Dun Hong; Yanfang Bao; Chen Wang; Weibo Pan
Journal:  Oncol Lett       Date:  2013-08-23       Impact factor: 2.967

7.  Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach.

Authors:  Eric S J Harris; Shugeng Cao; Sean D Schoville; Chengming Dong; Wenquan Wang; Zaiyou Jian; Zhongzhen Zhao; David M Eisenberg; Jon Clardy
Journal:  PLoS One       Date:  2012-11-27       Impact factor: 3.240

8.  Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis.

Authors:  Jia-Jun Liu; Yong Zhang; Wei-Bin Guang; Hong-Zhi Yang; Dong-Jun Lin; Ruo-Zhi Xiao
Journal:  Int J Mol Sci       Date:  2008-11-19       Impact factor: 6.208

9.  Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines.

Authors:  Lynn S Adams; Navindra P Seeram; Mary L Hardy; Catherine Carpenter; David Heber
Journal:  Evid Based Complement Alternat Med       Date:  2006-03       Impact factor: 2.629

10.  Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1.

Authors:  S M Sagar; D Yance; R K Wong
Journal:  Curr Oncol       Date:  2006-02       Impact factor: 3.677
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