BACKGROUND: The brunt of the human immunodeficiency virus infection/the acquired immunodeficiency syndrome is largely borne by communities in sub-Saharan Africa. We describe renal disease in Nigerians with the acquired immunodeficiency syndrome. METHODS: Consecutive patients with the acquired immunodeficiency syndrome (AIDS) seen in the infections unit of the Jos University Teaching Hospital and a similar group of healthy controls were evaluated for renal disease. Subjects with past history of renal disease, hypovolemia, hypertension, diabetes mellitus and/or a documented fever were excluded from the study. RESULTS: Of the 79 patients with the acquired immunodeficiency syndrome and 57 controls studied, renal disease was present in 41 (51.8%) of the patients in the AIDS group and 7 (12.2%) of controls. While 15 (19%) of the AIDS group had azotemia alone and 20 (25.3%) had proteinuria alone, 6 (7.6%) had azotemia and proteinuria. The mean protein excretion/24 hours was significantly higher in the AIDS group compared to controls, (2.99 +/- 54 g and 0.56 +/- 0.12 g respectively, p = 0.001), while the GFR was significantly higher in controls compared to the study group (103.30 +/- 37.78 and 68.03 +/- 37.55 respectively, p = 0.004). Subjects in the AIDS group with renal disease had a significantly longer duration of illness compared to those without (12.33 +/- 8.67 months and 7.28 +/- 7.78 months respectively, p = 0.008). Age and serum CD4+ cell counts were similar in patients with and without renal disease in the AIDS group. CONCLUSION: Renal disease is a common complication of acquired immunodeficiency syndrome, the duration of illness being strongly associated with its presence.
BACKGROUND: The brunt of the human immunodeficiency virus infection/the acquired immunodeficiency syndrome is largely borne by communities in sub-Saharan Africa. We describe renal disease in Nigerians with the acquired immunodeficiency syndrome. METHODS: Consecutive patients with the acquired immunodeficiency syndrome (AIDS) seen in the infections unit of the Jos University Teaching Hospital and a similar group of healthy controls were evaluated for renal disease. Subjects with past history of renal disease, hypovolemia, hypertension, diabetes mellitus and/or a documented fever were excluded from the study. RESULTS: Of the 79 patients with the acquired immunodeficiency syndrome and 57 controls studied, renal disease was present in 41 (51.8%) of the patients in the AIDS group and 7 (12.2%) of controls. While 15 (19%) of the AIDS group had azotemia alone and 20 (25.3%) had proteinuria alone, 6 (7.6%) had azotemia and proteinuria. The mean protein excretion/24 hours was significantly higher in the AIDS group compared to controls, (2.99 +/- 54 g and 0.56 +/- 0.12 g respectively, p = 0.001), while the GFR was significantly higher in controls compared to the study group (103.30 +/- 37.78 and 68.03 +/- 37.55 respectively, p = 0.004). Subjects in the AIDS group with renal disease had a significantly longer duration of illness compared to those without (12.33 +/- 8.67 months and 7.28 +/- 7.78 months respectively, p = 0.008). Age and serum CD4+ cell counts were similar in patients with and without renal disease in the AIDS group. CONCLUSION:Renal disease is a common complication of acquired immunodeficiency syndrome, the duration of illness being strongly associated with its presence.
Authors: Dalili Mohammed Shabbal; Mustapha Abubakar Jamda; Ibrahim Tijjani Dalhatu; Muhammad Bashir Abdulrahman; Chris Isichei Journal: Niger Med J Date: 2014-11
Authors: David G Dillon; Deepti Gurdasani; Johanna Riha; Kenneth Ekoru; Gershim Asiki; Billy N Mayanja; Naomi S Levitt; Nigel J Crowther; Moffat Nyirenda; Marina Njelekela; Kaushik Ramaiya; Ousman Nyan; Olanisun O Adewole; Kathryn Anastos; Livio Azzoni; W Henry Boom; Caterina Compostella; Joel A Dave; Halima Dawood; Christian Erikstrup; Carla M Fourie; Henrik Friis; Annamarie Kruger; John A Idoko; Chris T Longenecker; Suzanne Mbondi; Japheth E Mukaya; Eugene Mutimura; Chiratidzo E Ndhlovu; George Praygod; Eric W Pefura Yone; Mar Pujades-Rodriguez; Nyagosya Range; Mahmoud U Sani; Aletta E Schutte; Karen Sliwa; Phyllis C Tien; Este H Vorster; Corinna Walsh; Rutendo Zinyama; Fredirick Mashili; Eugene Sobngwi; Clement Adebamowo; Anatoli Kamali; Janet Seeley; Elizabeth H Young; Liam Smeeth; Ayesha A Motala; Pontiano Kaleebu; Manjinder S Sandhu Journal: Int J Epidemiol Date: 2013-12 Impact factor: 7.196
Authors: Nazik Elmalaika Husain; Mohamed H Ahmed; Ahmed O Almobarak; Sufian K Noor; Wadie M Elmadhoun; Heitham Awadalla; Clare L Woodward; Dushyant Mital Journal: J Clin Med Res Date: 2017-12-01