Literature DB >> 14735533

Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway.

Herbert Waldmann1, Ioanna-Maria Karaguni, Mercedes Carpintero, Eleni Gourzoulidou, Christian Herrmann, Christoph Brockmann, Hartmut Oschkinat, Oliver Müller.   

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Year:  2004        PMID： 14735533     DOI： 10.1002/anie.200353089

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  27 in total

1.  Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.

Authors:  Till Maurer; Lindsay S Garrenton; Angela Oh; Keith Pitts; Daniel J Anderson; Nicholas J Skelton; Benjamin P Fauber; Borlan Pan; Shiva Malek; David Stokoe; Mary J C Ludlam; Krista K Bowman; Jiansheng Wu; Anthony M Giannetti; Melissa A Starovasnik; Ira Mellman; Peter K Jackson; Joachim Rudolph; Weiru Wang; Guowei Fang
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-19       Impact factor: 11.205

Review 2.  Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.

Authors:  Shaoyong Lu; Hyunbum Jang; Shuo Gu; Jian Zhang; Ruth Nussinov
Journal:  Chem Soc Rev       Date:  2016-07-11       Impact factor: 54.564

Review 3.  Drugging the undruggable RAS: Mission possible?

Authors:  Adrienne D Cox; Stephen W Fesik; Alec C Kimmelman; Ji Luo; Channing J Der
Journal:  Nat Rev Drug Discov       Date:  2014-10-17       Impact factor: 84.694

4.  Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.

Authors:  Luise Richter; Lisa-Marie Munter; Julia Ness; Peter W Hildebrand; Muralidhar Dasari; Stephanie Unterreitmeier; Bruno Bulic; Michael Beyermann; Ronald Gust; Bernd Reif; Sascha Weggen; Dieter Langosch; Gerd Multhaup
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-02       Impact factor: 11.205

5.  Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V).

Authors:  Adam M Levinson; John H McGee; Andrew G Roberts; Gardner S Creech; Ting Wang; Michael T Peterson; Ronald C Hendrickson; Gregory L Verdine; Samuel J Danishefsky
Journal:  J Am Chem Soc       Date:  2017-05-22       Impact factor: 15.419

Review 6.  The RAS-Effector Interaction as a Drug Target.

Authors:  Adam B Keeton; E Alan Salter; Gary A Piazza
Journal:  Cancer Res       Date:  2017-01-06       Impact factor: 12.701

Review 7.  Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design.

Authors:  Jonathan M L Ostrem; Kevan M Shokat
Journal:  Nat Rev Drug Discov       Date:  2016-07-29       Impact factor: 84.694

Review 8.  Small-molecule modulation of Ras signaling.

Authors:  Jochen Spiegel; Philipp M Cromm; Gunther Zimmermann; Tom N Grossmann; Herbert Waldmann
Journal:  Nat Chem Biol       Date:  2014-06-15       Impact factor: 15.040

9.  Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.

Authors:  Michael C Burns; Qi Sun; R Nathan Daniels; DeMarco Camper; J Phillip Kennedy; Jason Phan; Edward T Olejniczak; Taekyu Lee; Alex G Waterson; Olivia W Rossanese; Stephen W Fesik
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-18       Impact factor: 11.205

Review 10.  Therapeutic Approaches to RAS Mutation.

Authors:  Aaron J Scott; Christopher H Lieu; Wells A Messersmith
Journal:  Cancer J       Date:  2016 May-Jun       Impact factor: 3.360
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