Literature DB >> 14735532

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.

Oliver Müller1, Eleni Gourzoulidou, Mercedes Carpintero, Ioanna-Maria Karaguni, Anette Langerak, Christian Herrmann, Tarik Möröy, Ludger Klein-Hitpass, Herbert Waldmann.   

Abstract

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Year:  2004        PMID： 14735532     DOI： 10.1002/anie.200352587

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  11 in total

1.  Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.

Authors:  Luise Richter; Lisa-Marie Munter; Julia Ness; Peter W Hildebrand; Muralidhar Dasari; Stephanie Unterreitmeier; Bruno Bulic; Michael Beyermann; Ronald Gust; Bernd Reif; Sascha Weggen; Dieter Langosch; Gerd Multhaup
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-02       Impact factor: 11.205

Review 2.  Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design.

Authors:  Jonathan M L Ostrem; Kevan M Shokat
Journal:  Nat Rev Drug Discov       Date:  2016-07-29       Impact factor: 84.694

Review 3.  Small-molecule modulation of Ras signaling.

Authors:  Jochen Spiegel; Philipp M Cromm; Gunther Zimmermann; Tom N Grossmann; Herbert Waldmann
Journal:  Nat Chem Biol       Date:  2014-06-15       Impact factor: 15.040

4.  Small-molecule inhibition of APT1 affects Ras localization and signaling.

Authors:  Frank J Dekker; Oliver Rocks; Nachiket Vartak; Sascha Menninger; Christian Hedberg; Rengarajan Balamurugan; Stefan Wetzel; Steffen Renner; Marc Gerauer; Beate Schölermann; Marion Rusch; John W Kramer; Daniel Rauh; Geoffrey W Coates; Luc Brunsveld; Philippe I H Bastiaens; Herbert Waldmann
Journal:  Nat Chem Biol       Date:  2010-04-25       Impact factor: 15.040

5.  Inhibition of Ras-Effector Interaction by Cyclic Peptides.

Authors:  Xianghong Wu; Punit Upadhyaya; Miguel A Villalona-Calero; Roger Briesewitz; Dehua Pei
Journal:  Medchemcomm       Date:  2013-02-01       Impact factor: 3.597

Review 6.  Therapeutic Approaches to RAS Mutation.

Authors:  Aaron J Scott; Christopher H Lieu; Wells A Messersmith
Journal:  Cancer J       Date:  2016 May-Jun       Impact factor: 3.360

7.  Anti-angiogenic properties of a sulindac analogue.

Authors:  A Pyriochou; S Tsigkos; T Vassilakopoulos; T Cottin; Z Zhou; E Gourzoulidou; C Roussos; H Waldmann; A Giannis; A Papapetropoulos
Journal:  Br J Pharmacol       Date:  2007-10-29       Impact factor: 8.739

8.  Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed C-H Functionalization and Spiroannulation.

Authors:  Suresh Reddy Chidipudi; David J Burns; Imtiaz Khan; Hon Wai Lam
Journal:  Angew Chem Int Ed Engl       Date:  2015-09-25       Impact factor: 15.336

9.  Facile synthesis and preferred conformation analysis of cyclododeceno[b]indene.

Authors:  Chunyan Zhang; Shengyan Gong; Li Zhang; Daoquan Wang; Mingan Wang
Journal:  Molecules       Date:  2010-02-01       Impact factor: 4.411

10.  Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.

Authors:  Tudor I Oprea; Larry A Sklar; Jacob O Agola; Yuna Guo; Melina Silberberg; Joshua Roxby; Anna Vestling; Elsa Romero; Zurab Surviladze; Cristina Murray-Krezan; Anna Waller; Oleg Ursu; Laurie G Hudson; Angela Wandinger-Ness
Journal:  PLoS One       Date:  2015-11-11       Impact factor: 3.240
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