| Literature DB >> 14735434 |
Sung Hee Lee1, Ji-Xing Nan, Yu Zhe Zhao, Sun Wook Woo, Eun-Jeon Park, Tai-Hyun Kang, Geom Seog Seo, Youn-Chul Kim, Dong Hwan Sohn.
Abstract
Butein is known to be the major component of the bark of Rhus verniciflua Stokes (Anacardiaceae). The aim of this work was to investigate the effects of butein on liver fibrosis induced by carbon tetrachloride (CCl4) in rats, and to explore its antifibrogenic mechanism. Butein (10 mg/kg/day or 25 mg/kg/day) showed a significant reduction of hydroxyproline and malondialdehyde levels in rats. The expression of alpha1(I) collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNAs in liver was clearly reduced in a dose-dependent manner in rats given butein compared with control CCl4-treated rats. These data suggest the potential of butein to serve as an antifibrogenic agent by inhibition of collagen accumulation and lipid peroxidation, and by down-regulation of the expression of both alpha1(I) collagen and TIMP-1 mRNA.Entities:
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Year: 2003 PMID： 14735434 DOI： 10.1055/s-2003-45143
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352