OBJECTIVE: Among variants of the butyrylcholinesterase gene ( BChE), the K-variant causing Ala539Thr substitution is the most common one associated with about one-third reduction in the enzyme activity. This study aimed to detect the frequency of the K-variant allele in a Turkish population sample and also to evaluate how the plasma BChE activity was influenced by this variant. METHODS: Patients administered for elective surgery ( n=77) were examined for the presence of the K allele. The enzyme activity was determined in plasma. RESULTS: The K-variant of BChE is a common allele with a frequency of 0.266 (CI(95%) 0.196-0.336) in our sample from a Turkish population. Mean enzyme activity in subjects homozygous for the K-variant was about 40% lower than other subjects. CONCLUSION: The frequency of the BChE K-variant was significantly higher in a Turkish population than those reported for other populations and it is associated with a diminished enzyme activity.
OBJECTIVE: Among variants of the butyrylcholinesterase gene ( BChE), the K-variant causing Ala539Thr substitution is the most common one associated with about one-third reduction in the enzyme activity. This study aimed to detect the frequency of the K-variant allele in a Turkish population sample and also to evaluate how the plasma BChE activity was influenced by this variant. METHODS:Patients administered for elective surgery ( n=77) were examined for the presence of the K allele. The enzyme activity was determined in plasma. RESULTS: The K-variant of BChE is a common allele with a frequency of 0.266 (CI(95%) 0.196-0.336) in our sample from a Turkish population. Mean enzyme activity in subjects homozygous for the K-variant was about 40% lower than other subjects. CONCLUSION: The frequency of the BChE K-variant was significantly higher in a Turkish population than those reported for other populations and it is associated with a diminished enzyme activity.
Authors: C F Bartels; F S Jensen; O Lockridge; A F van der Spek; H M Rubinstein; T Lubrano; B N La Du Journal: Am J Hum Genet Date: 1992-05 Impact factor: 11.025
Authors: Larissa O Guimarães; Fabiana A de Andrade; Gleyse F Bono; Thaís E Setoguchi; Mariana B Brandão; Eleidi A Chautard-Freire-Maia; Izabella C R Dos Santos; Geraldo Picheth; Ana Cristina R de A Faria; Rosângela R Réa; Ricardo L R Souza; Lupe Furtado-Alle Journal: Genet Mol Biol Date: 2013-02-28 Impact factor: 1.771
Authors: Susan Searles Nielsen; Roberta McKean-Cowdin; Federico M Farin; Elizabeth A Holly; Susan Preston-Martin; Beth A Mueller Journal: Environ Health Perspect Date: 2010-01 Impact factor: 9.031