PURPOSE: A retrospective cohort mortality study based on standardized mortality ratios (SMRs) was conducted to investigate the possible association between exposure to chlorinated organic solvents and various types of cancer deaths. METHODS: Vital status and causes of death of study subjects were determined from January 1, 1985 to December 31, 1997 by linking cohort data with the National Mortality Database. Person-year accumulation began on the date of entry to the cohort, or January 1, 1985 (whichever came later), and ended on the closing date of the study (December 31, 1997), if alive; or the date of death. RESULTS: This retrospective cohort study examined cancer mortality among 86,868 workers at an electronics factory in the northern Taiwan. Using various durations of employment and latency and adjusting for age and calendar year, no significantly elevated SMR was found for any cancer in either male or female exposed workers when compared with the general Taiwanese population. In particular, the risk of female breast cancer was not found to be increased. Although ovarian cancer suggested an upward trend when analyzed by length of employment, ovarian cancer risk for the entire female cohort was not elevated. CONCLUSIONS: It is concluded that this study provided no evidence that exposure to chlorinated organic solvents was associated with human cancer risk.
PURPOSE: A retrospective cohort mortality study based on standardized mortality ratios (SMRs) was conducted to investigate the possible association between exposure to chlorinated organic solvents and various types of cancer deaths. METHODS: Vital status and causes of death of study subjects were determined from January 1, 1985 to December 31, 1997 by linking cohort data with the National Mortality Database. Person-year accumulation began on the date of entry to the cohort, or January 1, 1985 (whichever came later), and ended on the closing date of the study (December 31, 1997), if alive; or the date of death. RESULTS: This retrospective cohort study examined cancer mortality among 86,868 workers at an electronics factory in the northern Taiwan. Using various durations of employment and latency and adjusting for age and calendar year, no significantly elevated SMR was found for any cancer in either male or female exposed workers when compared with the general Taiwanese population. In particular, the risk of female breast cancer was not found to be increased. Although ovarian cancer suggested an upward trend when analyzed by length of employment, ovarian cancer risk for the entire female cohort was not elevated. CONCLUSIONS: It is concluded that this study provided no evidence that exposure to chlorinated organic solvents was associated with humancancer risk.
Authors: J H Mandel; M A Kelsh; P J Mink; D D Alexander; R M Kalmes; M Weingart; L Yost; M Goodman Journal: Occup Environ Med Date: 2006-04-27 Impact factor: 4.402
Authors: Dominik D Alexander; Michael A Kelsh; Pamela J Mink; Jeffrey H Mandel; Rupa Basu; Michal Weingart Journal: Int Arch Occup Environ Health Date: 2007-05-10 Impact factor: 2.851
Authors: David J Press; Meg McKinley; Dennis Deapen; Christina A Clarke; Scarlett Lin Gomez Journal: Cancer Causes Control Date: 2016-03-17 Impact factor: 2.532