Literature DB >> 14732024

Functions of pRb and p53: what's the connection?

T Kouzarides1.   

Abstract

The pRb and p53 proteins have tumour suppressor functions and both are regulators of transcription. Their mechanisms of transcriptional regulation are unrelated in many ways--in contrast, it would appear, to their biological functions. This review highlights their biological connections in the light of recent advances in understanding the mechanisms of pRb and p53 function.

Entities:  

Year:  1995        PMID： 14732024     DOI： 10.1016/s0962-8924(00)89109-6

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  6 in total

1.  YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, and YY1 and E1A cooperate to amplify p53 promoter activity.

Authors:  E E Furlong; T Rein; F Martin
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

2.  p53 expression induces apoptosis in hippocampal pyramidal neuron cultures.

Authors:  J Jordán; M F Galindo; J H Prehn; R R Weichselbaum; M Beckett; G D Ghadge; R P Roos; J M Leiden; R J Miller
Journal:  J Neurosci       Date:  1997-02-15       Impact factor: 6.167

3.  Tobacco smoke: chemical carcinogenesis and genetic lesions.

Authors:  J L Cook
Journal:  Ochsner J       Date:  1999-07

4.  Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

Authors:  R U Jänicke; P A Walker; X Y Lin; A G Porter
Journal:  EMBO J       Date:  1996-12-16       Impact factor: 11.598

Review 5.  Caspases: the executioners of apoptosis.

Authors:  G M Cohen
Journal:  Biochem J       Date:  1997-08-15       Impact factor: 3.857

6.  The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells.

Authors:  T J Collard; B C Urban; H A Patsos; A Hague; P A Townsend; C Paraskeva; A C Williams
Journal:  Cell Death Dis       Date:  2012-10-11       Impact factor: 8.469
  6 in total

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