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Literature DB >> 14731690

The Fas/APO-1 receptor and its deadly ligand.

Abstract

The cell surface receptor Fas/APO-1 and its ligand have recently been identified as important mediators of apoptosis. Both molecules are crucial for the maintenance of a sound immune system, and when defective they give rise to severe autoimmune disorders. Understanding the mechanism and regulation of Fas/APO-1-triggered cell death promises important insights for the pathogenesis of AIDS, cancer and autoimmune diseases.

Entities: Disease Gene

Year: 1994 PMID： 14731690 DOI： 10.1016/0962-8924(94)90102-3

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

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Cited

8 in total

1. Inhibition of apoptosis by ionomycin and zinc in peripheral blood mononuclear cells (PBMC) of leprosy patients.

Authors: A Gupta; V K Sharma; H Vohra; N K Ganguly
Journal: Clin Exp Immunol Date: 1999-07 Impact factor: 4.330

2. Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death.

Authors: P Mehlen; C Kretz-Remy; X Préville; A P Arrigo
Journal: EMBO J Date: 1996-06-03 Impact factor: 11.598

Review 3. Hypoxia, ischaemia, and apoptosis.

Authors: H Mehmet; A D Edwards
Journal: Arch Dis Child Fetal Neonatal Ed Date: 1996-09 Impact factor: 5.747

Review 4. Fas expression and apoptosis in human B cells.

Authors: E Schattner; S M Friedman
Journal: Immunol Res Date: 1996 Impact factor: 2.829

5. Fas ligand is not only expressed in immune privileged human organs but is also coexpressed with Fas in various epithelial tissues.

Authors: L Xerri; E Devilard; J Hassoun; C Mawas; F Birg
Journal: Mol Pathol Date: 1997-04

The Fas/APO-1 receptor and its deadly ligand.

1. Inhibition of apoptosis by ionomycin and zinc in peripheral blood mononuclear cells (PBMC) of leprosy patients.

2. Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death.

Review 3. Hypoxia, ischaemia, and apoptosis.

Review 4. Fas expression and apoptosis in human B cells.

5. Fas ligand is not only expressed in immune privileged human organs but is also coexpressed with Fas in various epithelial tissues.

Review 6. Apoptosis in the heart: when and why?

7. Lymphocytes apoptosis in patients with acute exacerbation of asthma.

8. Transitional B cells are the target of negative selection in the B cell compartment.