Literature DB >> 14731477

The nucleation-release model of actin filament dynamics in cell motility.

J A Theriot1, T J Mitchison.   

Abstract

The actin cytoskeleton is intimately involved in the motile behaviour of animal cells. The structure and dynamic behaviour of actin and its binding proteins have been intensively studied in vitro over the past several decades, culminating in achievements such as an atomic model of the actin filament. Despite this progress, it is not yet clear how the behaviour of these purified proteins in vitro relates to the dynamic behaviour of actin inside living, moving cells. Here we discuss a new model that relates the known dynamic parameters for pure actin to the observed behaviour of actin filaments inside motile cells.

Year:  1992        PMID： 14731477     DOI： 10.1016/0962-8924(92)90298-2

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  17 in total

1.  Modulation of actin filament behavior by GAP-43 (neuromodulin) is dependent on the phosphorylation status of serine 41, the protein kinase C site.

Authors:  Q He; E W Dent; K F Meiri
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

Review 2.  Compare and contrast actin filaments and microtubules.

Authors:  T J Mitchison
Journal:  Mol Biol Cell       Date:  1992-12       Impact factor: 4.138

3.  Investigation of the mechanism of retraction of the cell margin and rearward flow of nodules during mitotic cell rounding.

Authors:  L P Cramer; T J Mitchison
Journal:  Mol Biol Cell       Date:  1997-01       Impact factor: 4.138

4.  Single-molecule fluorescence imaging of processive myosin with enhanced background suppression using linear zero-mode waveguides (ZMWs) and convex lens induced confinement (CLIC).

Authors:  Mary Williard Elting; Sabrina R Leslie; L Stirling Churchman; Jonas Korlach; Christopher M J McFaul; Jason S Leith; Michael J Levene; Adam E Cohen; James A Spudich
Journal:  Opt Express       Date:  2013-01-14       Impact factor: 3.894

5.  Dynamic actin structures stabilized by profilin.

Authors:  T Finkel; J A Theriot; K R Dise; G F Tomaselli; P J Goldschmidt-Clermont
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

6.  X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates.

Authors:  A A Fedorov; K A Magnus; M H Graupe; E E Lattman; T D Pollard; S C Almo
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-30       Impact factor: 11.205

7.  Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells.

Authors:  R A Brundage; G A Smith; A Camilli; J A Theriot; D A Portnoy
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

8.  Actin Turnover in Lamellipodial Fragments.

Authors:  Dikla Raz-Ben Aroush; Noa Ofer; Enas Abu-Shah; Jun Allard; Oleg Krichevsky; Alex Mogilner; Kinneret Keren
Journal:  Curr Biol       Date:  2017-09-28       Impact factor: 10.834

9.  Modulation of the interaction between G-actin and thymosin beta 4 by the ATP/ADP ratio: possible implication in the regulation of actin dynamics.

Authors:  M F Carlier; C Jean; K J Rieger; M Lenfant; D Pantaloni
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

10.  A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin-based cytoskeleton of mammalian cells.

Authors:  T Chakraborty; F Ebel; E Domann; K Niebuhr; B Gerstel; S Pistor; C J Temm-Grove; B M Jockusch; M Reinhard; U Walter
Journal:  EMBO J       Date:  1995-04-03       Impact factor: 11.598
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