Literature DB >> 14731389

Regulation of p53 by Mdm2: fate is in the numbers.

Ayelet Shmueli1, Moshe Oren.   

Abstract

The p53 tumor suppressor protein is normally restrained by the Mdm2 oncoprotein, which promotes p53 ubiquitination. In a recent issue of Science, report that p53 may face two alternative fates, depending on Mdm2 levels: high Mdm2 drives p53 polyubiquitination and degradation within the cell nucleus, whereas low Mdm2 promotes p53 monoubiquitination and nuclear exclusion.

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Year:  2004        PMID： 14731389     DOI： 10.1016/s1097-2765(03)00529-x

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  15 in total

1.  Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

Authors:  Ekaterina Gresko; Ana Roscic; Stefanie Ritterhoff; Anton Vichalkovski; Giannino del Sal; M Lienhard Schmitz
Journal:  EMBO J       Date:  2006-04-06       Impact factor: 11.598

2.  Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells.

Authors:  Peeyush N Goel; R P Gude
Journal:  Mol Cell Biochem       Date:  2011-07-03       Impact factor: 3.396

3.  A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2.

Authors:  Karim M ElSawy; Adelene Sim; David P Lane; Chandra S Verma; Leo Sd Caves
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

4.  Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo.

Authors:  Harumi Shimizu; David Saliba; Maura Wallace; Lee Finlan; Patrick R R Langridge-Smith; Ted R Hupp
Journal:  Biochem J       Date:  2006-07-15       Impact factor: 3.857

5.  Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function.

Authors:  Daniel M Aebersold; Yoav D Shaul; Yuval Yung; Nirit Yarom; Zhong Yao; Tamar Hanoch; Rony Seger
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

6.  On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.

Authors:  Karim M ElSawy; Chandra S Verma; Thomas L Joseph; David P Lane; Reidun Twarock; Leo S D Caves
Journal:  Cell Cycle       Date:  2013-01-16       Impact factor: 4.534

7.  Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.

Authors:  C S Busso; T Iwakuma; T Izumi
Journal:  Oncogene       Date:  2009-02-16       Impact factor: 9.867

8.  Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53.

Authors:  Sreerama Shetty; Praveenkumar Shetty; Steven Idell; Thirunavukkarasu Velusamy; Yashodhar P Bhandary; Rashmi S Shetty
Journal:  J Biol Chem       Date:  2008-05-09       Impact factor: 5.157

9.  Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome.

Authors:  Meghan L Vyleta; John Wong; Bruce E Magun
Journal:  PLoS One       Date:  2012-05-14       Impact factor: 3.240

10.  Computational studies of difference in binding modes of peptide and non-peptide inhibitors to MDM2/MDMX based on molecular dynamics simulations.

Authors:  Jianzhong Chen; Dinglin Zhang; Yuxin Zhang; Guohui Li
Journal:  Int J Mol Sci       Date:  2012-02-17       Impact factor: 6.208
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