PURPOSE: To investigate barrier repair after mild trauma in lesional skin of psoriasis patients with chronic plaque-type disease and to compare this with non-involved psoriatic skin and normal controls. METHODS: Transepidermal water loss (TEWL) readings were taken from involved psoriatic skin and non-involved skin of psoriasis patients as well as the skin of normal controls. Three readings were performed at each site: the basal state, immediately after 20 tape strippings and 1 week post stripping. RESULTS: Higher baseline, post-stripping and 1-week recovery TEWL readings in psoriatic-involved skin compared to non-involved and normal control skin. No significant difference in barrier recovery rate in psoriatic-involved skin compared to non-involved and normal control. CONCLUSION: Although there appears to be a derangement of barrier function in lesional skin of psoriasis patients compared to non-lesional skin and the skin of healthy controls, the barrier recovery function of lesional psoriatic skin is still fully operational.
PURPOSE: To investigate barrier repair after mild trauma in lesional skin of psoriasispatients with chronic plaque-type disease and to compare this with non-involved psoriatic skin and normal controls. METHODS: Transepidermal water loss (TEWL) readings were taken from involved psoriatic skin and non-involved skin of psoriasispatients as well as the skin of normal controls. Three readings were performed at each site: the basal state, immediately after 20 tape strippings and 1 week post stripping. RESULTS: Higher baseline, post-stripping and 1-week recovery TEWL readings in psoriatic-involved skin compared to non-involved and normal control skin. No significant difference in barrier recovery rate in psoriatic-involved skin compared to non-involved and normal control. CONCLUSION: Although there appears to be a derangement of barrier function in lesional skin of psoriasispatients compared to non-lesional skin and the skin of healthy controls, the barrier recovery function of lesional psoriatic skin is still fully operational.
Authors: Shujun Xin; Wenyan Man; Joachim W Fluhr; Shunpeng Song; Peter M Elias; Mao-Qiang Man Journal: Skin Res Technol Date: 2010-11 Impact factor: 2.365
Authors: Rajan P Nair; Philip E Stuart; Ioana Nistor; Ravi Hiremagalore; Nicholas V C Chia; Stefan Jenisch; Michael Weichenthal; Gonçalo R Abecasis; Henry W Lim; Enno Christophers; John J Voorhees; James T Elder Journal: Am J Hum Genet Date: 2006-03-31 Impact factor: 11.025