| Literature DB >> 14730358 |
Christophe Nicot1, Miroslav Dundr, Julie M Johnson, Jake R Fullen, Norma Alonzo, Risaku Fukumoto, Gerald L Princler, David Derse, Tom Misteli, Genoveffa Franchini.
Abstract
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) persists despite a vigorous virus-specific host immune response, and causes adult T-cell leukemia and lymphoma in approximately 2% of infected individuals. Here we report that HTLV-1 has evolved a genetic function to restrict its own replication by a novel post-transcriptional mechanism. The HTLV-1-encoded p30(II) is a nuclear-resident protein that binds to, and retains in the nucleus, the doubly spliced mRNA encoding the Tax and Rex proteins. Because Tex and Rex are positive regulators of viral gene expression, their inhibition by p30(II) reduces virion production. p30(II) inhibits virus expression by reducing Tax and Rex protein expression.Entities:
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Year: 2004 PMID： 14730358 DOI： 10.1038/nm984
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440