Literature DB >> 14729144

Genetic instability in EBV-transformed lymphoblastoid cell lines.

Aisha Mohyuddin1, Qasim Ayub, Saima Siddiqi, Denise R Carvalho-Silva, Kehkashan Mazhar, Sadia Rehman, Sadaf Firasat, Ahsana Dar, Chris Tyler-Smith, S Qasim Mehdi.   

Abstract

Epstein Barr virus (EBV)-transformed lymphoblastoid cell lines are commonly used to provide an inexhaustible supply of DNA. We examined microsatellite instability in these cell lines in 35 individuals where DNA was available from the original blood samples and from cultured cell lines. Mutations were observed in 0.3% of the analyses, thus providing a quantitative measure of somatic mutation rate.

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Year:  2004        PMID： 14729144     DOI： 10.1016/j.bbagen.2003.10.014

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  A comprehensive survey of human Y-chromosomal microsatellites.

Authors:  Manfred Kayser; Ralf Kittler; Axel Erler; Minttu Hedman; Andrew C Lee; Aisha Mohyuddin; S Qasim Mehdi; Zoë Rosser; Mark Stoneking; Mark A Jobling; Antti Sajantila; Chris Tyler-Smith
Journal:  Am J Hum Genet       Date:  2004-06       Impact factor: 11.025

Review 2.  DNA Commission of the International Society of Forensic Genetics (ISFG): an update of the recommendations on the use of Y-STRs in forensic analysis.

Authors:  L Gusmão; J M Butler; A Carracedo; P Gill; M Kayser; W R Mayr; N Morling; M Prinz; L Roewer; C Tyler-Smith; P M Schneider
Journal:  Int J Legal Med       Date:  2006-07       Impact factor: 2.686

3.  Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines.

Authors:  Hiroko Sugawara; Kazuya Iwamoto; Miki Bundo; Junko Ueda; Jun Ishigooka; Tadafumi Kato
Journal:  Epigenetics       Date:  2011-04-01       Impact factor: 4.528

4.  A Simple Red Blood Cell Lysis Method for the Establishment of B Lymphoblastoid Cell Lines.

Authors:  Xi Liu; Chongfeng Xu; Ziyuan Duan
Journal:  J Vis Exp       Date:  2017-01-14       Impact factor: 1.355

5.  Robust imaging and gene delivery to study human lymphoblastoid cell lines.

Authors:  Lachlan A Jolly; Ying Sun; Renée Carroll; Claire C Homan; Jozef Gecz
Journal:  J Hum Genet       Date:  2018-06-20       Impact factor: 3.172

6.  Extensive epigenetic and transcriptomic variability between genetically identical human B-lymphoblastoid cells with implications in pharmacogenomics research.

Authors:  Lilla Ozgyin; Attila Horvath; Zsuzsanna Hevessy; Balint L Balint
Journal:  Sci Rep       Date:  2019-03-20       Impact factor: 4.379

7.  Single-cell RNA sequencing of a European and an African lymphoblastoid cell line.

Authors:  Daniel Osorio; Xue Yu; Peng Yu; Erchin Serpedin; James J Cai
Journal:  Sci Data       Date:  2019-07-04       Impact factor: 6.444

8.  Human Y chromosome base-substitution mutation rate measured by direct sequencing in a deep-rooting pedigree.

Authors:  Yali Xue; Qiuju Wang; Quan Long; Bee Ling Ng; Harold Swerdlow; John Burton; Carl Skuce; Ruth Taylor; Zahra Abdellah; Yali Zhao; Daniel G MacArthur; Michael A Quail; Nigel P Carter; Huanming Yang; Chris Tyler-Smith
Journal:  Curr Biol       Date:  2009-08-27       Impact factor: 10.834

Review 9.  Lymphoblastoid Cell lines: a Continuous in Vitro Source of Cells to Study Carcinogen Sensitivity and DNA Repair.

Authors:  Tabish Hussain; Rita Mulherkar
Journal:  Int J Mol Cell Med       Date:  2012
  9 in total

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