Literature DB >> 1472790

The succinate dehydrogenase inhibition test for evaluating biopsy specimens and resected tumors of advanced gastric cancer.

H Kimura1, Y Yonemura, S Ohyama, K Tsugawa, K Kinoshita, I Ninomiya, T Kosaka, K Miwa, I Miyazaki, M Tanaka.   

Abstract

An in vitro chemosensitivity study of both biopsy specimens and surgically resected tumors of advanced gastric cancer from 12 patients was evaluated using the succinate dehydrogenase inhibition (SDI) test. A decrease in succinate dehydrogenase (SD) activity as an indicator of chemosensitivity was determined using cisplatin (CDDP), etoposide (VP-16), and mitomycin C (MMC). In this study, 29 of a total 36 experiments were evaluable (80.6%) and significant correlations were found in all three of the antitumor drugs (P < 0.03). This finding suggests that the SDI test using biopsy specimens may prove valuable for assessing the preoperative chemosensitivity of advanced gastric cancer.

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Year:  1992        PMID： 1472790     DOI： 10.1007/bf00308895

Source DB:  PubMed          Journal:  Surg Today        ISSN： 0941-1291            Impact factor:   2.549


  18 in total

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Authors:  Y Maehara; S Kohnoe; K Sugimachi
Journal:  Semin Surg Oncol       Date:  1990

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Authors:  X de Aretxabala; Y Yonemura; K Sugiyama; N Hirose; T Kumaki; S Fushida; K Miwa; I Miyazaki
Journal:  Cancer       Date:  1989-02-15       Impact factor: 6.860

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Authors:  T Nakashima; T Uemura; Y Maehara; K Sugimachi
Journal:  Oncology       Date:  1989       Impact factor: 2.935

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Authors:  T Kondo; T Imamura; H Ichihashi
Journal:  Gan       Date:  1966-04

5.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors:  T Mosmann
Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

6.  Sensitivity to six antitumor drugs differs between primary and metastatic liver cancers.

Authors:  T Kanematsu; Y Maehara; T Kusumoto; K Sugimachi
Journal:  Eur J Cancer Clin Oncol       Date:  1988-09

7.  [In vitro chemosensitivity of various human tumors evaluated by the SDI (succinate dehydrogenase inhibition) test].

Authors:  Y Maehara; H Anai; H Masuda; R Tamada; K Sugimachi; K Inokuchi
Journal:  Gan To Kagaku Ryoho       Date:  1985-10

8.  Prediction of response of tumor and host to cancer chemotherapy.

Authors:  T Kondo
Journal:  Natl Cancer Inst Monogr       Date:  1971-12

9.  Flow cytometric quantitation of the proliferation-associated nuclear antigen p105 and DNA content in advanced gastric cancers.

Authors:  H Kimura; Y Yonemura; A L Epstein
Journal:  Cancer       Date:  1991-11-15       Impact factor: 6.860

10.  Comparison between succinate dehydrogenase inhibition test and subrenal capsule assay for chemosensitivity testing.

Authors:  H Anai; Y Maehara; H Kusumoto; K Sugimachi
Journal:  Oncology       Date:  1987       Impact factor: 2.935
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  1 in total

1.  In Vitro Drug Sensitivity Tests to Predict Molecular Target Drug Responses in Surgically Resected Lung Cancer.

Authors:  Ryohei Miyazaki; Takashi Anayama; Kentaro Hirohashi; Hironobu Okada; Motohiko Kume; Kazumasa Orihashi
Journal:  PLoS One       Date:  2016-04-12       Impact factor: 3.240
  1 in total

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