Literature DB >> 14727867

Effect of additives on the release of a model protein from PLGA microspheres.

F Kang1, J Singh.   

Abstract

The purpose of this study was to investigate the effect of 2 additives, poly(ethylene glycol) (PEG) 1000 and 1,2,3-tridecanoyl glycerol (tricaprin), on the physico-chemical characteristics and in vitro release of a model protein, bovine serum albumin (BSA), form poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres. BSA-loaded microspheres were prepared by the double emulsion solvent evaporation method. Additives were incorporated into microspheres to modify the release of protein. The addition of PEG 1000 and tricaprin changed the surface characteristics of microspheres from smooth and nonporous to porous and dimpled, respectively. The in vitro release profiles showed that the additives significantly (P < 0.05) increased the early-stage release of BSA from microspheres.

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Year:  2001        PMID： 14727867      PMCID： PMC2784845          DOI： 10.1208/pt020430

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN： 1530-9932            Impact factor:   3.246


  15 in total

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Journal:  Pharm Res       Date:  2001-06       Impact factor: 4.200

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  8 in total

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Journal:  AAPS PharmSciTech       Date:  2003       Impact factor: 3.246

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7.  Dimensionality reduction, and function approximation of poly(lactic-co-glycolic acid) micro- and nanoparticle dissolution rate.

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Journal:  Int J Nanomedicine       Date:  2015-02-04

8.  Heuristic modeling of macromolecule release from PLGA microspheres.

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  8 in total

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