Literature DB >> 14727142

Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.

Lars Hornum1, Cheryl DeScipio, Helle Markholst, Scott A Troutman, Stephen Novak, Jean Leif, Dale Greiner, John P Mordes, Elizabeth P Blankenhorn.   

Abstract

Iddm4 is one of several susceptibility genes that have been identified in the BB rat model of type 1 diabetes. The BB rat allele of this gene confers dominant predisposition to diabetes induction by immune perturbation in both the diabetes-prone and the diabetes-resistant substrains, whereas the Wistar Furth (WF) allele confers resistance. We have positioned the gene in a 2.8-cM region on rat Chromosome (Chr) 4, proximal to Lyp/Ian4l1. We have produced a radiation hybrid map of the Iddm4-region that includes a number of rat genes with their mouse and human orthologs. We present a comparative map of the rat Iddm4 region in rat, human, and mouse, assigning the gene to a 6.3-Mb segment between PTN and ZYX at 7q32 in the human genome, and to a 5.7-Mb segment between Ptn and Zyx in the mouse genome.

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Year:  2004        PMID： 14727142     DOI： 10.1007/s00335-003-3023-z

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  17 in total

1.  Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells.

Authors:  H Luo; X Wan; Y Wu; J Wu
Journal:  J Immunol       Date:  2001-08-01       Impact factor: 5.422

2.  Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.

Authors:  A M Martin; E P Blankenhorn; M N Maxson; M Zhao; J Leif; J P Mordes; D L Greiner
Journal:  Diabetes       Date:  1999-01       Impact factor: 9.461

3.  Statistical methods for polyploid radiation hybrid mapping.

Authors:  K Lange; M Boehnke; D R Cox; K L Lunetta
Journal:  Genome Res       Date:  1995-09       Impact factor: 9.043

Review 4.  Type 1 diabetes: new perspectives on disease pathogenesis and treatment.

Authors:  M A Atkinson; G S Eisenbarth
Journal:  Lancet       Date:  2001-07-21       Impact factor: 79.321

5.  Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption.

Authors:  J B Peng; X Z Chen; U V Berger; P M Vassilev; H Tsukaguchi; E M Brown; M A Hediger
Journal:  J Biol Chem       Date:  1999-08-06       Impact factor: 5.157

6.  Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation.

Authors:  A Botta; E A Lindsay; V Jurecic; A Baldini
Journal:  Mamm Genome       Date:  1997-12       Impact factor: 2.957

7.  Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens.

Authors:  V A Thomas; B A Woda; E S Handler; D L Greiner; J P Mordes; A A Rossini
Journal:  Diabetes       Date:  1991-02       Impact factor: 9.461

8.  Expression, genomic structure and mapping of the thymus specific protease prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility.

Authors:  Saijai Cheunsuk; Rachel Sparks; Janice K Noveroske; Tom Hsu; Monica J Justice; M Eric Gershwin; Jeffrey R Gruen; Christopher L Bowlus
Journal:  J Autoimmun       Date:  2002-06       Impact factor: 7.094

9.  Evolutionary parameters of the transcribed mammalian genome: an analysis of 2,820 orthologous rodent and human sequences.

Authors:  W Makalowski; M S Boguski
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-04       Impact factor: 11.205

10.  DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity.

Authors:  B J Whalen; A A Rossini; J P Mordes; D L Greiner
Journal:  Diabetes       Date:  1995-08       Impact factor: 9.461
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  4 in total

1.  The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.

Authors:  Elizabeth P Blankenhorn; Lucy Rodemich; Cristina Martin-Fernandez; Jean Leif; Dale L Greiner; John P Mordes
Journal:  Diabetes       Date:  2005-04       Impact factor: 9.461

2.  Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.

Authors:  Heike Weiss; Andre Bleich; Hans-Jürgen Hedrich; Bernd Kölsch; Matthias Elsner; Anne Jörns; Sigurd Lenzen; Markus Tiedge; Dirk Wedekind
Journal:  Mamm Genome       Date:  2005-06       Impact factor: 2.957

3.  Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vβ13 as a therapeutic target and biomarker.

Authors:  Zhijun Liu; Laura Cort; Ryan Eberwine; Thomas Herrmann; Jean H Leif; Dale L Greiner; Barak Yahalom; Elizabeth P Blankenhorn; John P Mordes
Journal:  Diabetes       Date:  2012-02-24       Impact factor: 9.461

4.  The Missing Heritability in T1D and Potential New Targets for Prevention.

Authors:  Brian G Pierce; Ryan Eberwine; Janelle A Noble; Michael Habib; Hennady P Shulha; Zhiping Weng; Elizabeth P Blankenhorn; John P Mordes
Journal:  J Diabetes Res       Date:  2013-03-13       Impact factor: 4.011
  4 in total

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