Literature DB >> 14726675

p21(WAF1/CIP1) mediates the growth response to TGF-beta in human epithelial cells.

Kurtis E Bachman1, Brian G Blair, Keith Brenner, Alberto Bardelli, Sabrina Arena, Shibin Zhou, Jessica Hicks, Angelo M De Marzo, Pedram Argani, Ben Ho Park.   

Abstract

We investigated the mechanism by which cancers evade the growth inhibitory effects of TGF-beta. Using two p21-/- somatically deleted human epithelial cell lines, we find that TGF-beta serves as a growth stimulator rather than a growth suppressor to cells lacking p21. In addition, TGF-beta stimulated p21-/- cells exhibited a mesenchymal phenotype, demonstrated by an upregulation of vimentin and decreased expression of E-cadherin. Analysis of primary human breast cancers by immunohistochemical labeling confirmed a correlation between p21 loss and positive vimentin expression. These data provide a molecular mechanism explaining how nongastrointestinal cancers can escape the anti-proliferative effects of this cytokine and simultaneously use this pathway for growth advantage.

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Year:  2004        PMID： 14726675     DOI： 10.4161/cbt.3.2.666

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN： 1538-4047            Impact factor:   4.742


  25 in total

1.  A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster.

Authors:  Xiao Ling Li; Toshifumi Hara; Youngeun Choi; Murugan Subramanian; Princy Francis; Sven Bilke; Robert L Walker; Marbin Pineda; Yuelin Zhu; Yuan Yang; Ji Luo; Lalage M Wakefield; Thomas Brabletz; Ben Ho Park; Sudha Sharma; Dipanjan Chowdhury; Paul S Meltzer; Ashish Lal
Journal:  Mol Cell Biol       Date:  2013-11-25       Impact factor: 4.272

Review 2.  Transforming growth factor-β and atherosclerosis: interwoven atherogenic and atheroprotective aspects.

Authors:  Ian Toma; Timothy A McCaffrey
Journal:  Cell Tissue Res       Date:  2011-05-31       Impact factor: 5.249

3.  Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype.

Authors:  Adam D Pierce; Ian E Anglin; Michele I Vitolo; Maria T Mochin; Karen F Underwood; Simeon E Goldblum; Sravya Kommineni; Antonino Passaniti
Journal:  J Cell Biochem       Date:  2012-01       Impact factor: 4.429

4.  Differential regulation of p21 (waf1) protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications.

Authors:  Li-Ju Chang; Alan Eastman
Journal:  Cancer Biol Ther       Date:  2012-07-24       Impact factor: 4.742

5.  Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue.

Authors:  Hui Cheng; Cheng Chen; L U Liu; N A Zhan; Benhui Li
Journal:  Oncol Lett       Date:  2015-04-23       Impact factor: 2.967

6.  Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation.

Authors:  Grace M Wang; Hong Yuen Wong; Hiroyuki Konishi; Brian G Blair; Abde M Abukhdeir; John P Gustin; D Marc Rosen; Samuel Ray Denmeade; Zeshaan Rasheed; William Matsui; Joseph P Garay; Morassa Mohseni; Michaela J Higgins; Justin Cidado; Danijela Jelovac; Sarah Croessmann; Rory L Cochran; Sivasundaram Karnan; Yuko Konishi; Akinobu Ota; Yoshitaka Hosokawa; Pedram Argani; Josh Lauring; Ben Ho Park
Journal:  Cancer Res       Date:  2013-04-11       Impact factor: 12.701

7.  Tamoxifen-stimulated growth of breast cancer due to p21 loss.

Authors:  Abde M Abukhdeir; Michele I Vitolo; Pedram Argani; Angelo M De Marzo; Bedri Karakas; Hiroyuki Konishi; John P Gustin; Josh Lauring; Joseph P Garay; Courtney Pendleton; Yuko Konishi; Brian G Blair; Keith Brenner; Elizabeth Garrett-Mayer; Hetty Carraway; Kurtis E Bachman; Ben Ho Park
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-27       Impact factor: 11.205

8.  Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.

Authors:  Ulrich Valcourt; Sylvie Thuault; Katerina Pardali; Carl-Henrik Heldin; Aristidis Moustakas
Journal:  Mol Oncol       Date:  2007-03-14       Impact factor: 6.603

9.  P21waf1/cip1/sdi1 as a central regulator of inducible smooth muscle actin expression and differentiation of cardiac fibroblasts to myofibroblasts.

Authors:  Sashwati Roy; Savita Khanna; Trenton Rink; Jared Radtke; W Taylor Williams; Sabyasachi Biswas; Rebecca Schnitt; Arthur R Strauch; Chandan K Sen
Journal:  Mol Biol Cell       Date:  2007-09-19       Impact factor: 4.138

Review 10.  P21 and p27: roles in carcinogenesis and drug resistance.

Authors:  Abde M Abukhdeir; Ben Ho Park
Journal:  Expert Rev Mol Med       Date:  2008-07-01       Impact factor: 5.600
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