OBJECTIVES: Glomerular filtration rate (GFR) is the best overall index of renal function in health and disease. Recently, Cystatin C (Cyst C), a low molecular weight protein freely filtered through the glomerulus, and almost completely reabsorbed and catabolized by tubular cells, has been proposed as a new and very sensitive serum marker of change in GFR. This study investigated the relationship between Cyst C and creatinine (CR) in renal disease patients. METHODS: Serum Cyst C was determined by particle-enhanced immunoturbidimetry using the Cyst C PET-kit. The results could be obtained within 1 h. Cuvettes were washed before the Cyst C assay as recommended. Serum CR, BUN and albumin were determined by auto-analyzer. RESULTS: A strong correlation was observed between Cyst C and CR (P = 0.001, r = 0.764 and P = 0.0001, r = 0.888, respectively) in prehemodialysis (pre-HD) and kidney transplantation (Tx-kidney), whereas there was a weak correlation in continuous ambulatory peritoneal dialysis (CAPD) (P = 0.05, r = 0.535). CONCLUSION: These findings suggest that serum Cyst C may be considered as a sensitive predictive parameter for reduced GFR. It is of value for the laboratory diagnosis of chronic renal failure and should be preferentially used for CR clearance.
OBJECTIVES: Glomerular filtration rate (GFR) is the best overall index of renal function in health and disease. Recently, Cystatin C (Cyst C), a low molecular weight protein freely filtered through the glomerulus, and almost completely reabsorbed and catabolized by tubular cells, has been proposed as a new and very sensitive serum marker of change in GFR. This study investigated the relationship between Cyst C and creatinine (CR) in renal diseasepatients. METHODS: Serum Cyst C was determined by particle-enhanced immunoturbidimetry using the Cyst C PET-kit. The results could be obtained within 1 h. Cuvettes were washed before the Cyst C assay as recommended. Serum CR, BUN and albumin were determined by auto-analyzer. RESULTS: A strong correlation was observed between Cyst C and CR (P = 0.001, r = 0.764 and P = 0.0001, r = 0.888, respectively) in prehemodialysis (pre-HD) and kidney transplantation (Tx-kidney), whereas there was a weak correlation in continuous ambulatory peritoneal dialysis (CAPD) (P = 0.05, r = 0.535). CONCLUSION: These findings suggest that serum Cyst C may be considered as a sensitive predictive parameter for reduced GFR. It is of value for the laboratory diagnosis of chronic renal failure and should be preferentially used for CR clearance.
Authors: Joachim H Ix; Michael G Shlipak; Glenn M Chertow; Sadia Ali; Nelson B Schiller; Mary A Whooley Journal: J Card Fail Date: 2006-10 Impact factor: 5.712
Authors: Fatina I Fadel; Abbass A Mourad; Azza M O Abdel Rahman; Hafez M Bazaraa; Mohamed Farouk Mohamed; Dalia H El-Lebedy; Mohamed M Soliman Journal: Pediatr Nephrol Date: 2017-04-17 Impact factor: 3.714
Authors: Rajet Deo; Michael G Shlipak; Joachim H Ix; Sadia Ali; Nelson B Schiller; Mary A Whooley Journal: Clin Cardiol Date: 2009-11 Impact factor: 2.882