| Literature DB >> 14725931 |
Thomas J Lowery1, Seth M Rubin, E Janette Ruiz, Megan M Spence, Nicolas Winssinger, Peter G Schultz, Alexander Pines, David E Wemmer.
Abstract
The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and functionalized 129Xe NMR to in vitro biomolecular assays suggests the potential future use of a functionalized xenon biosensor for in vivo imaging.Entities:
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Year: 2003 PMID： 14725931 DOI： 10.1016/j.mri.2003.08.025
Source DB: PubMed Journal: Magn Reson Imaging ISSN： 0730-725X Impact factor: 2.546