Literature DB >> 14725347

In silico prediction of the structure of membrane proteins: is it feasible?

Rita Casadio1, Piero Fariselli, Pier Luigi Martelli.   

Abstract

In the 'omic' era, hundreds of genomes are available for protein sequence analysis, and some 30 per cent of all sequences are of membrane proteins. Unlike globular proteins, a 3D model for membrane proteins can hardly be computed starting from the sequence. Why is this so? What can we really compute and with what reliability? These and other matters are outlined.

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Year:  2003        PMID： 14725347     DOI： 10.1093/bib/4.4.341

Source DB:  PubMed          Journal:  Brief Bioinform        ISSN： 1467-5463            Impact factor:   11.622


  9 in total

1.  A graph-theoretic approach for classification and structure prediction of transmembrane β-barrel proteins.

Authors:  Van Du T Tran; Philippe Chassignet; Saad Sheikh; Jean-Marc Steyaert
Journal:  BMC Genomics       Date:  2012-04-12       Impact factor: 3.969

2.  Modeling the structural consequences of BEST1 missense mutations.

Authors:  Karina E Guziewicz; Gustavo D Aguirre; Barbara Zangerl
Journal:  Adv Exp Med Biol       Date:  2012       Impact factor: 2.622

3.  A comprehensive approach to identification of surface-exposed, outer membrane-spanning proteins of Leptospira interrogans.

Authors:  Marija Pinne; David A Haake
Journal:  PLoS One       Date:  2009-06-29       Impact factor: 3.240

4.  TRAMPLE: the transmembrane protein labelling environment.

Authors:  Piero Fariselli; Michele Finelli; Ivan Rossi; Mauro Amico; Andrea Zauli; Pier Luigi Martelli; Rita Casadio
Journal:  Nucleic Acids Res       Date:  2005-07-01       Impact factor: 16.971

5.  Beta barrel trans-membrane proteins: Enhanced prediction using a Bayesian approach.

Authors:  Paul D Taylor; Christopher P Toseland; Teresa K Attwood; Darren R Flower
Journal:  Bioinformation       Date:  2006-10-07

6.  A new decoding algorithm for hidden Markov models improves the prediction of the topology of all-beta membrane proteins.

Authors:  Piero Fariselli; Pier Luigi Martelli; Rita Casadio
Journal:  BMC Bioinformatics       Date:  2005-12-01       Impact factor: 3.169

7.  PONGO: a web server for multiple predictions of all-alpha transmembrane proteins.

Authors:  Mauro Amico; Michele Finelli; Ivan Rossi; Andrea Zauli; Arne Elofsson; Håkan Viklund; Gunnar von Heijne; David Jones; Anders Krogh; Piero Fariselli; Pier Luigi Martelli; Rita Casadio
Journal:  Nucleic Acids Res       Date:  2006-07-01       Impact factor: 16.971

8.  A predictor of membrane class: Discriminating alpha-helical and beta-barrel membrane proteins from non-membranous proteins.

Authors:  Paul D Taylor; Christopher P Toseland; Teresa K Attwood; Darren R Flower
Journal:  Bioinformation       Date:  2006-10-07

9.  Alpha helical trans-membrane proteins: Enhanced prediction using a Bayesian approach.

Authors:  Paul D Taylor; Christopher P Toseland; Teresa K Attwood; Darren R Flower
Journal:  Bioinformation       Date:  2006-11-14
  9 in total

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