BACKGROUND: Neuroendocrine carcinoma (NEC) is a rare malignancy of the nasal cavity or paranasal sinuses. The syndrome of inappropriate ADH secretion (SIADH) has not been previously reported in association with this cancer. METHODS: We report a 30-year-old woman with histologically confirmed neuroendocrine carcinoma who also demonstrated SIADH. After successful chemotherapy and radiotherapy treatment for the neoplasm, her SIADH resolved. A literature search found eight cases of olfactory neuroblastoma (ONB) associated with SIADH, four of which resolved after treatment of the malignancy. RESULTS: Treatment of the underlying malignancy resulted in the immediate resolution of the SIADH. CONCLUSIONS: We report the first case of SIADH associated with NEC, which resolved after treatment of the cancer. A direct cause and effect between ONB/nasal NEC and SIADH has been established in previous reports. Copyright 2004 Wiley Periodicals, Inc.
BACKGROUND:Neuroendocrine carcinoma (NEC) is a rare malignancy of the nasal cavity or paranasal sinuses. The syndrome of inappropriate ADH secretion (SIADH) has not been previously reported in association with this cancer. METHODS: We report a 30-year-old woman with histologically confirmed neuroendocrine carcinoma who also demonstrated SIADH. After successful chemotherapy and radiotherapy treatment for the neoplasm, her SIADH resolved. A literature search found eight cases of olfactory neuroblastoma (ONB) associated with SIADH, four of which resolved after treatment of the malignancy. RESULTS: Treatment of the underlying malignancy resulted in the immediate resolution of the SIADH. CONCLUSIONS: We report the first case of SIADH associated with NEC, which resolved after treatment of the cancer. A direct cause and effect between ONB/nasal NEC and SIADH has been established in previous reports. Copyright 2004 Wiley Periodicals, Inc.
Authors: Alfio Ferlito; Alessandra Rinaldo; Justin A Bishop; Jennifer L Hunt; Vincent Vander Poorten; Michelle D Williams; Asterios Triantafyllou; Kenneth O Devaney; Douglas R Gnepp; Kimihide Kusafuka; Gyorgy B Halmos; William H Westra; Robert P Takes; Lester D R Thompson Journal: Eur Arch Otorhinolaryngol Date: 2014-10-29 Impact factor: 2.503