Literature DB >> 1472470

Oncogenic transformation by Jun: role of transactivation and homodimerization.

M Hartl1, P K Vogt.   

Abstract

Jun/JunD and Jun/GCN4 chimeras transform chicken embryo fibroblasts and activate the collagenase promoter in these same cells. Individual constructs differ widely in the two activities, and there is no correlation between transformation and transactivation. These results suggest that oncogenic transformation by Jun is not caused merely by an upregulation of AP-1 activity. Jun constructs with a modified dimerization domain allowing only homodimerization are active in transformation and transactivation in chicken embryo fibroblast cultures. Homodimers of Jun therefore transform and transactivate.

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Year:  1992        PMID： 1472470

Source DB:  PubMed          Journal:  Cell Growth Differ        ISSN： 1044-9523


  12 in total

1.  Specific activation in jun-transformed avian fibroblasts of a gene (bkj) related to the avian beta-keratin gene family.

Authors:  M Hartl; K Bister
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-05       Impact factor: 11.205

Review 2.  Age-associated chronic diseases require age-old medicine: role of chronic inflammation.

Authors:  Sahdeo Prasad; Bokyung Sung; Bharat B Aggarwal
Journal:  Prev Med       Date:  2011-12-09       Impact factor: 4.018

3.  Proliferative activation of quiescent Rat-1A cells by delta FosB.

Authors:  Y Nakabeppu; S Oda; M Sekiguchi
Journal:  Mol Cell Biol       Date:  1993-07       Impact factor: 4.272

4.  Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.

Authors:  K Kataoka; K Igarashi; K Itoh; K T Fujiwara; M Noda; M Yamamoto; M Nishizawa
Journal:  Mol Cell Biol       Date:  1995-04       Impact factor: 4.272

5.  Transformation by the fos or jun oncogene does not increase AP-1 DNA-binding activity.

Authors:  K L Hawker; A Pintzas; R F Hennigan; D A Gillespie; B W Ozanne
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

6.  MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun.

Authors:  K Kataoka; K T Fujiwara; M Noda; M Nishizawa
Journal:  Mol Cell Biol       Date:  1994-11       Impact factor: 4.272

7.  JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2.

Authors:  T Kameda; A Akahori; M H Sonobe; T Suzuki; T Endo; H Iba
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

8.  Homodimerization of Marek's disease virus-encoded Meq protein is not sufficient for transformation of lymphocytes in chickens.

Authors:  Paulette F Suchodolski; Yoshihiro Izumiya; Blanca Lupiani; Dharani K Ajithdoss; Oren Gilad; Lucy F Lee; Hsing-Jien Kung; Sanjay M Reddy
Journal:  J Virol       Date:  2008-10-29       Impact factor: 5.103

9.  Transcription factor ATF2 cooperates with v-Jun to promote growth factor-independent proliferation in vitro and tumor formation in vivo.

Authors:  S Huguier; J Baguet; S Perez; H van Dam; M Castellazzi
Journal:  Mol Cell Biol       Date:  1998-12       Impact factor: 4.272

10.  JNK/AP-1 pathway is involved in tumor necrosis factor-alpha induced expression of vascular endothelial growth factor in MCF7 cells.

Authors:  Yongmei Yin; Shui Wang; Yujie Sun; Young Matt; Nancy H Colburn; Yongqian Shu; Xiao Han
Journal:  Biomed Pharmacother       Date:  2009-06-09       Impact factor: 6.529
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