Literature DB >> 14723623

Immunological crossreactivity of the Mycobacterium leprae CFP-10 with its homologue in Mycobacterium tuberculosis.

A Geluk1, K E van Meijgaarden, K L M C Franken, B Wieles, S M Arend, W R Faber, B Naafs, T H M Ottenhoff.   

Abstract

Mycobacterium tuberculosis culture filtrate protein-10 (CFP-10) (Rv3874) is considered a promising antigen for the immunodiagnosis of tuberculosis (TB) together with early secreted antigens of M. tuberculosis (ESAT-6). Both ESAT-6 and CFP-10 are encoded by the RD1 region that is deleted from all tested M. bovis bacille Calmette-Guérin (BCG) strains but present in M. leprae, M. tuberculosis, M. bovis, M. kansasii, M. africanum and M. marinum. In this study, the homologue of CFP-10 in M. leprae (ML0050) is identified and characterized. Interferon-gamma production in response to this homologue by T cells from leprosy patients, TB patients and unexposed controls shows that CFP-10 of M. leprae is a potent antigen that crossreacts with CFP-10 of M. tuberculosis at the T-cell level. This crossreactivity has implications for the use of CFP-10 of these mycobacterial species as diagnostic tool in areas endemic for both the diseases.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 14723623     DOI： 10.1111/j.0300-9475.2004.01358.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN： 0300-9475            Impact factor:   3.487


  26 in total

1.  Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection.

Authors:  Annemieke Geluk; Michèl R Klein; Kees L M C Franken; Krista E van Meijgaarden; Brigitte Wieles; Kelly Cristina Pereira; Samira Bührer-Sékula; Paul R Klatser; Patrick J Brennan; John S Spencer; Diana L Williams; Maria C V Pessolani; Elizabeth P Sampaio; Tom H M Ottenhoff
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

2.  An improved whole-blood gamma interferon assay based on the CFP21-MPT64 fusion protein.

Authors:  Ruiling Fu; Chun Wang; Chunwei Shi; Mengji Lu; Zhengming Fang; Jia Lu; Fang Wang; Xionglin Fan
Journal:  Clin Vaccine Immunol       Date:  2009-03-11

3.  Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states.

Authors:  William Richard Berrington; Murdo Macdonald; Saraswoti Khadge; Bishwa Raj Sapkota; Marta Janer; Deanna Alisa Hagge; Gilla Kaplan; Thomas Richard Hawn
Journal:  J Infect Dis       Date:  2010-05-01       Impact factor: 5.226

4.  Protection against Mycobacterium leprae infection by the ID83/GLA-SE and ID93/GLA-SE vaccines developed for tuberculosis.

Authors:  Malcolm S Duthie; Rhea N Coler; John D Laurance; Lucas H Sampaio; Regiane M Oliveira; Ana Lucia M Sousa; Mariane M A Stefani; Yumi Maeda; Masanori Matsuoka; Masahiko Makino; Steven G Reed
Journal:  Infect Immun       Date:  2014-07-14       Impact factor: 3.441

5.  Gene expression profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real-time PCR.

Authors:  Hee Jin Kim; Kalyani Prithiviraj; Nathan Groathouse; Patrick J Brennan; John S Spencer
Journal:  Clin Vaccine Immunol       Date:  2012-12-12

Review 6.  Gamma interferon release assays for detection of Mycobacterium tuberculosis infection.

Authors:  Madhukar Pai; Claudia M Denkinger; Sandra V Kik; Molebogeng X Rangaka; Alice Zwerling; Olivia Oxlade; John Z Metcalfe; Adithya Cattamanchi; David W Dowdy; Keertan Dheda; Niaz Banaei
Journal:  Clin Microbiol Rev       Date:  2014-01       Impact factor: 26.132

7.  Antibody responses in reindeer (Rangifer tarandus) infected with Mycobacterium bovis.

Authors:  W R Waters; M V Palmer; J P Bannantine; R Greenwald; J Esfandiari; P Andersen; J McNair; J M Pollock; K P Lyashchenko
Journal:  Clin Diagn Lab Immunol       Date:  2005-06

8.  From genome-based in silico predictions to ex vivo verification of leprosy diagnosis.

Authors:  Annemieke Geluk; John S Spencer; Kidist Bobosha; Maria C V Pessolani; Geraldo M B Pereira; Sayera Banu; Nadine Honoré; Stephen T Reece; Murdo MacDonald; Bishwa Raj Sapkota; Chaman Ranjit; Kees L M C Franken; Martha Zewdie; Abraham Aseffa; Rabia Hussain; Mariane M Stefani; Sang-Nae Cho; Linda Oskam; Patrick J Brennan; Hazel M Dockrell
Journal:  Clin Vaccine Immunol       Date:  2009-01-28

9.  Use of recombinant ESAT-6:CFP-10 fusion protein for differentiation of infections of cattle by Mycobacterium bovis and by M. avium subsp. avium and M. avium subsp. paratuberculosis.

Authors:  W R Waters; B J Nonnecke; M V Palmer; S Robbe-Austermann; J P Bannantine; J R Stabel; D L Whipple; J B Payeur; D M Estes; J E Pitzer; F C Minion
Journal:  Clin Diagn Lab Immunol       Date:  2004-07

10.  Silencing Mycobacterium smegmatis by using tetracycline repressors.

Authors:  Xinzheng V Guo; Mercedes Monteleone; Marcus Klotzsche; Annette Kamionka; Wolfgang Hillen; Miriam Braunstein; Sabine Ehrt; Dirk Schnappinger
Journal:  J Bacteriol       Date:  2007-05-04       Impact factor: 3.490
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.