| Literature DB >> 1472314 |
Abstract
The intake of alcohol, in 2-h daily sessions, by the preferring (P) line of rats was reduced in a dose-related manner by acute subcutaneous (SC) administration of dexfenfluramine (DFEN). Ad lib intake of alcohol was reduced by chronic SC administration of DFEN. The effective doses and magnitude of effects of DFEN on alcohol intake are comparable to those previously reported for DFEN anorexia. Because DFEN anorexia is related to increased brain serotonin (5HT) activity, its effect on alcohol consumption may also be via 5HT.Entities:
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Year: 1992 PMID： 1472314 DOI： 10.1016/0741-8329(92)90097-t
Source DB: PubMed Journal: Alcohol ISSN： 0741-8329 Impact factor: 2.405