Literature DB >> 1472085

Synergism in vitro of lovastatin and miconazole as anti-leishmanial agents.

P A Haughan1, M L Chance, L J Goad.   

Abstract

The antifungal drug miconazole and the cholesterol-lowering agent lovastatin (mevinolin) were used in combination to assess their potency as anti-leishmanial agents. The drug combination was synergistic, being more potent in terms of inhibition of promastigote proliferation, macrophage infection and amastigote numbers. In promastigote cultures the effect was more marked in Leishmania amazonensis than L. donovani. Analysis of the sterol compositions of both promastigote and amastigote cultures revealed the inhibition of sterol 14 alpha-demethylation by miconazole and showed some apparent evidence of inhibition of sterol biosynthesis by lovastatin.

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Year:  1992        PMID： 1472085     DOI： 10.1016/0006-2952(92)90347-l

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  15 in total

1.  Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.

Authors:  A Montalvetti; J Peña-Díaz; R Hurtado; L M Ruiz-Pérez; D González-Pacanowska
Journal:  Biochem J       Date:  2000-07-01       Impact factor: 3.857

2.  Production and characterization of stable amphotericin-resistant amastigotes and promastigotes of Leishmania mexicana.

Authors:  Hamdan I Al-Mohammed; Michael L Chance; Paul A Bates
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

3.  Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors.

Authors:  F S Buckner; J H Griffin; A J Wilson; W C Van Voorhis
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

4.  Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes.

Authors:  H Rangel; F Dagger; A Hernandez; A Liendo; J A Urbina
Journal:  Antimicrob Agents Chemother       Date:  1996-12       Impact factor: 5.191

5.  Effects of an azasterol inhibitor of sterol 24-transmethylation on sterol biosynthesis and growth of Leishmania donovani promastigotes.

Authors:  P A Haughan; M L Chance; L J Goad
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857

Review 6.  Translating biosynthetic gene clusters into fungal armor and weaponry.

Authors:  Nancy P Keller
Journal:  Nat Chem Biol       Date:  2015-09       Impact factor: 15.040

7.  A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

Authors:  Frederick Buckner; Kohei Yokoyama; Jeffrey Lockman; Kendra Aikenhead; Junko Ohkanda; Martin Sadilek; Said Sebti; Wesley Van Voorhis; Andrew Hamilton; Michael H Gelb
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

8.  Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In Vitro Synergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis.

Authors:  Valter Viana Andrade-Neto; Edézio Ferreira Cunha-Júnior; Marilene Marcuzzo do Canto-Cavalheiro; Geórgia Correa Atella; Talita de Almeida Fernandes; Paulo Roberto Ribeiro Costa; Eduardo Caio Torres-Santos
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

9.  Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and application of statins as a novel effective therapeutic approach against Acanthamoeba infections.

Authors:  Carmen María Martín-Navarro; Jacob Lorenzo-Morales; Rubén P Machin; Atteneri López-Arencibia; José Manuel García-Castellano; Isabel de Fuentes; Brendan Loftus; Sutherland K Maciver; Basilio Valladares; José E Piñero
Journal:  Antimicrob Agents Chemother       Date:  2012-10-31       Impact factor: 5.191

10.  Host cholesterol influences the activity of sterol biosynthesis inhibitors in Leishmania amazonensis.

Authors:  Valter Viana Andrade-Neto; Pedro Paulo de Abreu Manso; Miria Gomes Pereira; Nuccia Nicole Theodoro de Cicco; Georgia Corrêa Atella; Marcelo Pelajo-Machado; Rubem Figueiredo Sadok Menna-Barreto; Eduardo Caio Torres-Santos
Journal:  Mem Inst Oswaldo Cruz       Date:  2022-04-04       Impact factor: 2.743
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