T Lombardi1, J Samson, F Plantier, C Husson, R Küffer. 1. Laboratory of Histopathology, Division of Stomatology, Faculty of Medicine, University of Geneva, Switzerland. Tommaso.Lombardi@medecine.unige.ch
Abstract
BACKGROUND: Purposely, cosmetic injections in orofacial tissues of various resorbable, biodegradable, or permanent fillers may be followed by development of foreign-body granulomas. The aim of this article is to contribute to the histologic identification of the filler material. METHODS: Histologic and clinical features of 11 cases of granulomas on orofacial fillers are described. RESULTS: Only 3/11 patients knew the nature of the injected product. Four histologic patterns were found: (i) Artecoll, (ii) Dermalive, and (iii) New-Fill granuloma, all three of the classic giant cell granuloma type, differing in respect of foreign particles; and (iv) Liquid Silicone granuloma, which featured a cystic and macrophagic type. Information was often missing or misleading, patients or practitioners being reluctant to give the details. CONCLUSION: Increasing demand for orofacial tissue augmentation makes pathologists face new, and sometimes, puzzling granuloma types. Identification of the foreign product might be required for therapeutic or medico-legal reasons.
BACKGROUND: Purposely, cosmetic injections in orofacial tissues of various resorbable, biodegradable, or permanent fillers may be followed by development of foreign-body granulomas. The aim of this article is to contribute to the histologic identification of the filler material. METHODS: Histologic and clinical features of 11 cases of granulomas on orofacial fillers are described. RESULTS: Only 3/11 patients knew the nature of the injected product. Four histologic patterns were found: (i) Artecoll, (ii) Dermalive, and (iii) New-Fill granuloma, all three of the classic giant cell granuloma type, differing in respect of foreign particles; and (iv) Liquid Siliconegranuloma, which featured a cystic and macrophagic type. Information was often missing or misleading, patients or practitioners being reluctant to give the details. CONCLUSION: Increasing demand for orofacial tissue augmentation makes pathologists face new, and sometimes, puzzling granuloma types. Identification of the foreign product might be required for therapeutic or medico-legal reasons.
Authors: Adriele Ferreira Gouvêa; João Adolfo Costa Hanemann; Alessandro Antonio Costa Pereira; Ana Carolina Prado Ribeiro; Mário José Romañach; Jacks Jorge; Pablo Agustin Vargas Journal: Head Neck Pathol Date: 2010-11-03
Authors: Francesco Inchingolo; Marco Tatullo; Fabio M Abenavoli; Massimo Marrelli; Alessio D Inchingolo; Andrea Servili; Angelo M Inchingolo; Gianna Dipalma Journal: Head Face Med Date: 2010-07-15 Impact factor: 2.151